TY - JOUR
T1 - Intra-abdominal mass and iron deficiency anemia in a 15-year-old boy
T2 - Case report and literature review
AU - Martin, Kathryn
AU - Emmerton-Coughlin, Heather
AU - Butter, Andreana
N1 - Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2014/3
Y1 - 2014/3
N2 - Castleman's disease is rare lymphoproliferative disorder that typically presents as a mediastinal mass, although 10% of cases may be intra-abdominal. Given its rarity, diagnosis is often delayed until other pathology has been ruled out. We present the case of a 15-year-old boy with a one-year history of progressive fatigue, failure to thrive, and severe iron resistant, iron deficiency anemia. Extensive work-up revealed an intra-abdominal mass. At laparotomy, a discrete lymphoid-appearing mass was found at the base of the mesentery. Excision led to rapid and complete resolution of his symptoms, including resolution of anemia. Pathology demonstrated Castleman's disease of the hyaline vascular subtype. Increased awareness of this entity and its association with severe iron deficiency anemia though the overproduction of IL-6 may allow earlier detection and treatment.
AB - Castleman's disease is rare lymphoproliferative disorder that typically presents as a mediastinal mass, although 10% of cases may be intra-abdominal. Given its rarity, diagnosis is often delayed until other pathology has been ruled out. We present the case of a 15-year-old boy with a one-year history of progressive fatigue, failure to thrive, and severe iron resistant, iron deficiency anemia. Extensive work-up revealed an intra-abdominal mass. At laparotomy, a discrete lymphoid-appearing mass was found at the base of the mesentery. Excision led to rapid and complete resolution of his symptoms, including resolution of anemia. Pathology demonstrated Castleman's disease of the hyaline vascular subtype. Increased awareness of this entity and its association with severe iron deficiency anemia though the overproduction of IL-6 may allow earlier detection and treatment.
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U2 - 10.1016/j.epsc.2014.02.010
DO - 10.1016/j.epsc.2014.02.010
M3 - Article
AN - SCOPUS:84897474462
VL - 2
SP - 123
EP - 125
JO - Journal of Pediatric Surgery Case Reports
JF - Journal of Pediatric Surgery Case Reports
SN - 2213-5766
IS - 3
ER -