Intra-arterial chemotherapy for malignant gliomas: A critical analysis

J. K. Burkhardt, H. A. Riina, Benjamin J. Shin, J. A. Moliterno, C. P. Hofstetter, John A. Boockvar

Research output: Contribution to journalReview article

26 Citations (Scopus)

Abstract

Intra-arterial (IA) chemotherapy for malignant gliomas including glioblastoma multiforme was initiated decades ago, with many preclinical and clinical studies having been performed since then. Although novel endovascular devices and techniques such as microcatheter or balloon assistance have been introduced into clinical practice, the question remains whether IA therapy is safe and superior to other drug delivery modalities such as intravenous (IV) or oral treatment regimens. This review focuses on IA delivery and surveys the available literature to assess the advantages and disadvantages of IA chemotherapy for treatment of malignant gliomas. In addition, we introduce our hypothesis of using IA delivery to selectively target cancer stem cells residing in the perivascular stem cell niche.

Original languageEnglish (US)
Pages (from-to)286-295
Number of pages10
JournalInterventional Neuroradiology
Volume17
Issue number3
DOIs
StatePublished - Jan 1 2011

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Glioma
Drug Therapy
Stem Cell Niche
Endovascular Procedures
Neoplastic Stem Cells
Glioblastoma
Therapeutics
Equipment and Supplies
Pharmaceutical Preparations
Surveys and Questionnaires
Clinical Studies

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine

Cite this

Burkhardt, J. K., Riina, H. A., Shin, B. J., Moliterno, J. A., Hofstetter, C. P., & Boockvar, J. A. (2011). Intra-arterial chemotherapy for malignant gliomas: A critical analysis. Interventional Neuroradiology, 17(3), 286-295. https://doi.org/10.1177/159101991101700302
Burkhardt, J. K. ; Riina, H. A. ; Shin, Benjamin J. ; Moliterno, J. A. ; Hofstetter, C. P. ; Boockvar, John A. / Intra-arterial chemotherapy for malignant gliomas : A critical analysis. In: Interventional Neuroradiology. 2011 ; Vol. 17, No. 3. pp. 286-295.
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Burkhardt, JK, Riina, HA, Shin, BJ, Moliterno, JA, Hofstetter, CP & Boockvar, JA 2011, 'Intra-arterial chemotherapy for malignant gliomas: A critical analysis', Interventional Neuroradiology, vol. 17, no. 3, pp. 286-295. https://doi.org/10.1177/159101991101700302

Intra-arterial chemotherapy for malignant gliomas : A critical analysis. / Burkhardt, J. K.; Riina, H. A.; Shin, Benjamin J.; Moliterno, J. A.; Hofstetter, C. P.; Boockvar, John A.

In: Interventional Neuroradiology, Vol. 17, No. 3, 01.01.2011, p. 286-295.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Intra-arterial chemotherapy for malignant gliomas

T2 - A critical analysis

AU - Burkhardt, J. K.

AU - Riina, H. A.

AU - Shin, Benjamin J.

AU - Moliterno, J. A.

AU - Hofstetter, C. P.

AU - Boockvar, John A.

PY - 2011/1/1

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