Intracellular calcium release mediated by sphingosine derivatives generated in cells

Tarun K. Ghosh, Junhui Blan, Donald Gill

Research output: Contribution to journalArticle

310 Citations (Scopus)

Abstract

Soluble and hydrophobic lipid breakdown products have a variety of important signaling roles in cells. Here sphingoid bases derived in cells from sphingolipid breakdown are shown to have a potent and direct effect in mediating calcium release from intracellular stores. Sphingosine must be enzymically converted within the cell to a product believed to be sphingosine-1-phosphate, which thereafter effects calcium release from a pool including the inositol 1,4,5-trisphosphate-sensitive calcium pool. The sensitivity, molecular specificity, and reversibility of the effect on calcium movements closely parallel sphingoid base-mediated inhibition of protein kinase C. Generation of sphingoid bases in cells may activate a dual signaling pathway involving regulation ofcalcium and protein kinase C, comparable perhaps to the phosphatidylinositol and calcium signaling pathway.

Original languageEnglish (US)
Pages (from-to)1653-1656
Number of pages4
JournalScience
Volume248
Issue number4963
DOIs
StatePublished - Jan 1 1990

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Sphingosine
Calcium
Protein Kinase C
Sphingolipids
Inositol 1,4,5-Trisphosphate
Calcium Signaling
Phosphatidylinositols
Lipids
Sensitivity and Specificity

All Science Journal Classification (ASJC) codes

  • General

Cite this

Ghosh, Tarun K. ; Blan, Junhui ; Gill, Donald. / Intracellular calcium release mediated by sphingosine derivatives generated in cells. In: Science. 1990 ; Vol. 248, No. 4963. pp. 1653-1656.
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Intracellular calcium release mediated by sphingosine derivatives generated in cells. / Ghosh, Tarun K.; Blan, Junhui; Gill, Donald.

In: Science, Vol. 248, No. 4963, 01.01.1990, p. 1653-1656.

Research output: Contribution to journalArticle

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