Intracellular calcium release mediated by sphingosine derivatives generated in cells

Tarun K. Ghosh, Junhui Blan, Donald L. Gill

Research output: Contribution to journalArticlepeer-review

315 Scopus citations

Abstract

Soluble and hydrophobic lipid breakdown products have a variety of important signaling roles in cells. Here sphingoid bases derived in cells from sphingolipid breakdown are shown to have a potent and direct effect in mediating calcium release from intracellular stores. Sphingosine must be enzymically converted within the cell to a product believed to be sphingosine-1-phosphate, which thereafter effects calcium release from a pool including the inositol 1,4,5-trisphosphate-sensitive calcium pool. The sensitivity, molecular specificity, and reversibility of the effect on calcium movements closely parallel sphingoid base-mediated inhibition of protein kinase C. Generation of sphingoid bases in cells may activate a dual signaling pathway involving regulation ofcalcium and protein kinase C, comparable perhaps to the phosphatidylinositol and calcium signaling pathway.

Original languageEnglish (US)
Pages (from-to)1653-1656
Number of pages4
JournalScience
Volume248
Issue number4963
DOIs
StatePublished - 1990

All Science Journal Classification (ASJC) codes

  • General

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