Intracoronary adenosine and papaverine do not increase myocardial systolic thickening

R. Stefan Kiesz, J. Dwane Gehman, Joseph Gascho

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Study objective - The aim was to determine if myocardial systolic thickening increases when coronary flow is augmented by infusing intracoronary vasodilators (adenosine and papaverine).Design - Systolic thickening fraction was measured with pulsed Doppler crystals and sonomicrometer crystals before and during the intracoronary infusion of adenosine and papaverine.Subjects - Sixteen anaethetised mongrel dogs were studied.Measurements and main results - Intracoronary adenosine did not alter systemic haemodynamics, but did induce a three- to fourfold increase in myocardial blood flow. Intracoronary papaverine caused a slight decrease in systemic arterial pressure and rise in heart rate. Neither intracoronary adenosine nor intracoronary papaverine increased systolic thickening: control thickening fraction (TF%) = 20 (SEM 1)%, adenosine TF% = 18(1)%; control TF% = 22(2)%, papaverine TF% = 20(2)%.Conclusions - These experiments do not support the hypothesis that an increase in myocardial blood flow induced by intracoronary vasodilators causes an increase in myocardial systolic function.

Original languageEnglish (US)
Pages (from-to)1042-1050
Number of pages9
JournalCardiovascular Research
Volume25
Issue number12
DOIs
StatePublished - Jan 1 1991

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Papaverine
Adenosine
Vasodilator Agents
Arterial Pressure
Heart Rate
Hemodynamics
Dogs

All Science Journal Classification (ASJC) codes

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Kiesz, R. Stefan ; Gehman, J. Dwane ; Gascho, Joseph. / Intracoronary adenosine and papaverine do not increase myocardial systolic thickening. In: Cardiovascular Research. 1991 ; Vol. 25, No. 12. pp. 1042-1050.
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abstract = "Study objective - The aim was to determine if myocardial systolic thickening increases when coronary flow is augmented by infusing intracoronary vasodilators (adenosine and papaverine).Design - Systolic thickening fraction was measured with pulsed Doppler crystals and sonomicrometer crystals before and during the intracoronary infusion of adenosine and papaverine.Subjects - Sixteen anaethetised mongrel dogs were studied.Measurements and main results - Intracoronary adenosine did not alter systemic haemodynamics, but did induce a three- to fourfold increase in myocardial blood flow. Intracoronary papaverine caused a slight decrease in systemic arterial pressure and rise in heart rate. Neither intracoronary adenosine nor intracoronary papaverine increased systolic thickening: control thickening fraction (TF{\%}) = 20 (SEM 1){\%}, adenosine TF{\%} = 18(1){\%}; control TF{\%} = 22(2){\%}, papaverine TF{\%} = 20(2){\%}.Conclusions - These experiments do not support the hypothesis that an increase in myocardial blood flow induced by intracoronary vasodilators causes an increase in myocardial systolic function.",
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Intracoronary adenosine and papaverine do not increase myocardial systolic thickening. / Kiesz, R. Stefan; Gehman, J. Dwane; Gascho, Joseph.

In: Cardiovascular Research, Vol. 25, No. 12, 01.01.1991, p. 1042-1050.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Intracoronary adenosine and papaverine do not increase myocardial systolic thickening

AU - Kiesz, R. Stefan

AU - Gehman, J. Dwane

AU - Gascho, Joseph

PY - 1991/1/1

Y1 - 1991/1/1

N2 - Study objective - The aim was to determine if myocardial systolic thickening increases when coronary flow is augmented by infusing intracoronary vasodilators (adenosine and papaverine).Design - Systolic thickening fraction was measured with pulsed Doppler crystals and sonomicrometer crystals before and during the intracoronary infusion of adenosine and papaverine.Subjects - Sixteen anaethetised mongrel dogs were studied.Measurements and main results - Intracoronary adenosine did not alter systemic haemodynamics, but did induce a three- to fourfold increase in myocardial blood flow. Intracoronary papaverine caused a slight decrease in systemic arterial pressure and rise in heart rate. Neither intracoronary adenosine nor intracoronary papaverine increased systolic thickening: control thickening fraction (TF%) = 20 (SEM 1)%, adenosine TF% = 18(1)%; control TF% = 22(2)%, papaverine TF% = 20(2)%.Conclusions - These experiments do not support the hypothesis that an increase in myocardial blood flow induced by intracoronary vasodilators causes an increase in myocardial systolic function.

AB - Study objective - The aim was to determine if myocardial systolic thickening increases when coronary flow is augmented by infusing intracoronary vasodilators (adenosine and papaverine).Design - Systolic thickening fraction was measured with pulsed Doppler crystals and sonomicrometer crystals before and during the intracoronary infusion of adenosine and papaverine.Subjects - Sixteen anaethetised mongrel dogs were studied.Measurements and main results - Intracoronary adenosine did not alter systemic haemodynamics, but did induce a three- to fourfold increase in myocardial blood flow. Intracoronary papaverine caused a slight decrease in systemic arterial pressure and rise in heart rate. Neither intracoronary adenosine nor intracoronary papaverine increased systolic thickening: control thickening fraction (TF%) = 20 (SEM 1)%, adenosine TF% = 18(1)%; control TF% = 22(2)%, papaverine TF% = 20(2)%.Conclusions - These experiments do not support the hypothesis that an increase in myocardial blood flow induced by intracoronary vasodilators causes an increase in myocardial systolic function.

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