Intradermal sufentanil does not improve lidocaine-induced local anesthesia

Maximilian W.B. Hartmannsgruber, Peter G. Atanassoff, Arne Budde, Sorin J. Brull, Zeev N. Kain, David G. Silverman

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Purpose: Peripheral opioid receptors may result in antinociceptive effects when occupied by opioids. This study examined intradermally injected sufentanil (S), a highly lipid soluble opioid, administered with and without lidocaine (L), in a thermal pain model. Methods: Nine volunteers were instructed on the method of magnitude estimation of pain before undergoing baseline testing with seven seconds thermal stimuli between 44 and 52°C, delivered by a contact thermal stimulator at five cutaneous forearm sites. Then, four sites randomly received injections of equal volumes (0.1 mL) of either normal saline (NS), lidocaine 0.5% (L), sufentanil 0.75 μg (S), lidocaine 0.5% plus sufentanil 0.75 μg (L+S), and one site was not injected and served as reference (REF). Testing was repeated at six, 30, 60, 90, 120, and 150 min following injection. The pain elicited by each stimulus was normalized to the subject's response to the 50°C stimulus at the REF site. Results: Baseline testing showed small (P = ns) differences in pain scores. At six minutes, the lidocaine sites (L, L+S) had pain scores that were mean 83% (range 78-88%) lower than the other sites (P < 0.05), but there was no difference between the L and L+S sites or between the S and NS or REF sites. At 30 and 60 min these pain scores were mean 38% (29-44%) and 20% (8-30%) less than at the REF NS, and S sites (P = ns). At 90 min and later times, the pain scores had returned to baseline. Conclusions: These results suggest that intradermal sufentanil alone has no analgesic effect. Further, in combination with lidocaine, sufentanil does neither potentiate nor prolong the analgesic effect of lidocaine.

Original languageEnglish (US)
Pages (from-to)153-158
Number of pages6
JournalCanadian Journal of Anesthesia
Volume50
Issue number2
DOIs
StatePublished - Jan 1 2003

Fingerprint

Sufentanil
Local Anesthesia
Lidocaine
Pain
Hot Temperature
Opioid Analgesics
Analgesics
Injections
Opioid Receptors
Forearm
Volunteers
Lipids
Skin

All Science Journal Classification (ASJC) codes

  • Anesthesiology and Pain Medicine

Cite this

Hartmannsgruber, M. W. B., Atanassoff, P. G., Budde, A., Brull, S. J., Kain, Z. N., & Silverman, D. G. (2003). Intradermal sufentanil does not improve lidocaine-induced local anesthesia. Canadian Journal of Anesthesia, 50(2), 153-158. https://doi.org/10.1007/BF03017848
Hartmannsgruber, Maximilian W.B. ; Atanassoff, Peter G. ; Budde, Arne ; Brull, Sorin J. ; Kain, Zeev N. ; Silverman, David G. / Intradermal sufentanil does not improve lidocaine-induced local anesthesia. In: Canadian Journal of Anesthesia. 2003 ; Vol. 50, No. 2. pp. 153-158.
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Hartmannsgruber, MWB, Atanassoff, PG, Budde, A, Brull, SJ, Kain, ZN & Silverman, DG 2003, 'Intradermal sufentanil does not improve lidocaine-induced local anesthesia', Canadian Journal of Anesthesia, vol. 50, no. 2, pp. 153-158. https://doi.org/10.1007/BF03017848

Intradermal sufentanil does not improve lidocaine-induced local anesthesia. / Hartmannsgruber, Maximilian W.B.; Atanassoff, Peter G.; Budde, Arne; Brull, Sorin J.; Kain, Zeev N.; Silverman, David G.

In: Canadian Journal of Anesthesia, Vol. 50, No. 2, 01.01.2003, p. 153-158.

Research output: Contribution to journalArticle

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AB - Purpose: Peripheral opioid receptors may result in antinociceptive effects when occupied by opioids. This study examined intradermally injected sufentanil (S), a highly lipid soluble opioid, administered with and without lidocaine (L), in a thermal pain model. Methods: Nine volunteers were instructed on the method of magnitude estimation of pain before undergoing baseline testing with seven seconds thermal stimuli between 44 and 52°C, delivered by a contact thermal stimulator at five cutaneous forearm sites. Then, four sites randomly received injections of equal volumes (0.1 mL) of either normal saline (NS), lidocaine 0.5% (L), sufentanil 0.75 μg (S), lidocaine 0.5% plus sufentanil 0.75 μg (L+S), and one site was not injected and served as reference (REF). Testing was repeated at six, 30, 60, 90, 120, and 150 min following injection. The pain elicited by each stimulus was normalized to the subject's response to the 50°C stimulus at the REF site. Results: Baseline testing showed small (P = ns) differences in pain scores. At six minutes, the lidocaine sites (L, L+S) had pain scores that were mean 83% (range 78-88%) lower than the other sites (P < 0.05), but there was no difference between the L and L+S sites or between the S and NS or REF sites. At 30 and 60 min these pain scores were mean 38% (29-44%) and 20% (8-30%) less than at the REF NS, and S sites (P = ns). At 90 min and later times, the pain scores had returned to baseline. Conclusions: These results suggest that intradermal sufentanil alone has no analgesic effect. Further, in combination with lidocaine, sufentanil does neither potentiate nor prolong the analgesic effect of lidocaine.

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Hartmannsgruber MWB, Atanassoff PG, Budde A, Brull SJ, Kain ZN, Silverman DG. Intradermal sufentanil does not improve lidocaine-induced local anesthesia. Canadian Journal of Anesthesia. 2003 Jan 1;50(2):153-158. https://doi.org/10.1007/BF03017848