Intramolecular metal catalyzed kharasch cyclizations of olefinic α-halo esters and acids

Gary M. Lee, M. Parvez, Steven M. Weinreb

Research output: Contribution to journalArticle

56 Scopus citations

Abstract

Functionalized carbocyclic compounds are produced by intramolecular Kharasch radical cyclization reactions catalyzed by various transition metal complexes. Several unsaturated mono-α-haloesters and acids can be efficiently transformed to γ-halocarboxyl and γ-lactone carbocycles via exo closure of a 5-hexenyl type radical intermediate. The cyclization methodology is useful for synthesis of both fused and bridged carbocycles.

Original languageEnglish (US)
Pages (from-to)4671-4678
Number of pages8
JournalTetrahedron
Volume44
Issue number15
DOIs
StatePublished - Jan 1 1988

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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