A purified lipopolysaccharide Pseudomonas aeruginosa vaccine was administered via intranasal spray to cystic fibrosis patients in an attempt to induce development of local antibody without the side effects associated with parenteral administration of the vaccine. Although slight increases in serum antibody titers were noted, there was no appreciable change in specific antibody levels in parotid saliva or sputum following intranasal administration of the vaccine.
All Science Journal Classification (ASJC) codes
- Pediatrics, Perinatology, and Child Health
- Microbiology (medical)