Intraoperative brachytherapy for resected brain metastases

Sean S. Mahase, Kristina Navrazhina, Theodore H. Schwartz, Bhupesh Parashar, A. Gabriella Wernicke

Research output: Contribution to journalReview articlepeer-review

5 Scopus citations

Abstract

Brain metastases are the most common intracranial malignancies in adults. Surgical resection is the preferred treatment approach when a pathological diagnosis is required, for symptomatic patients who are refractory to steroids, and to decompress lesions causing mass effect. Radiotherapy is administered to improve local control rates after surgical resection. After a brief review of the literature describing the treatment of brain metastases using whole-brain radiotherapy, postoperative stereotactic radiosurgery, preoperative radiosurgery, and brachytherapy, we compare patient-related, technical, practical, and radiobiological considerations of each technique. Finally, we focus our discussion on intraoperative brachytherapy, with an emphasis on the technical aspects, benefits, efficacy, and outcomes of studies utilizing permanent Cs-131 implants.

Original languageEnglish (US)
Pages (from-to)258-270
Number of pages13
JournalBrachytherapy
Volume18
Issue number3
DOIs
StatePublished - May 1 2019

All Science Journal Classification (ASJC) codes

  • Oncology
  • Radiology Nuclear Medicine and imaging

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