Intrapartum antibiotics and childhood atopic dermatitis

Debra L. Wohl, William J. Curry, Dave Mauger, Jennifer Miller, Kaitlyn Tyrie

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

Introduction: Atopic dermatitis (AD) in children significantly impacts families because of medical costs, "lost" hours, and secondary characteristics such as asthma and ancillary infections. We investigate whether children delivered vaginally to women receiving intrapartum antibiotics have a greater risk of AD when younger than the age of 2 years than their counterparts. Methods: We conducted a retrospective analysis of women who delivered child(ren) vaginally between 1996 and 2008. Women were identified as those who received intrapartum antibiotics and those who did not. Pediatric records were used to determine the incidence of AD. Results: We collected data for 492 mother- child pairs. Intrapartum antibiotics were administered during 128 births; 28.9% of those children were diagnosed with AD by age 2 years (relative risk [RR], 1.03; 95% confidence interval [CI], 0.75-1.41). Factors with the greatest risk of diagnosis of AD by 2 years of age were intrapartum antibiotic exposure for >24 hours (RR, 1.99; 95% CI, 1.13-3.49), first born (RR, 1.78; 95% CI, 1.33-2.38), and higher maternal education (RR, 1.43; 95% CI, 0.99 -2.06). No statistical differences in the prevalence of AD related to parental eczema, maternal group B Streptococcus status, or gestational age existed. Conclusions: Exposure to antibiotics for <24 hours during a vaginal delivery does not increase the risk of AD. Studies are needed to understand whether exposure for >24 hours during the intrapartum period increases the risk of AD.

Original languageEnglish (US)
Pages (from-to)82-89
Number of pages8
JournalJournal of the American Board of Family Medicine
Volume28
Issue number1
DOIs
StatePublished - Jan 1 2015

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Atopic Dermatitis
Anti-Bacterial Agents
Confidence Intervals
Mothers
Streptococcus agalactiae
Eczema
Gestational Age
Asthma
Parturition
Pediatrics
Education
Costs and Cost Analysis
Incidence
Infection

All Science Journal Classification (ASJC) codes

  • Public Health, Environmental and Occupational Health
  • Family Practice

Cite this

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title = "Intrapartum antibiotics and childhood atopic dermatitis",
abstract = "Introduction: Atopic dermatitis (AD) in children significantly impacts families because of medical costs, {"}lost{"} hours, and secondary characteristics such as asthma and ancillary infections. We investigate whether children delivered vaginally to women receiving intrapartum antibiotics have a greater risk of AD when younger than the age of 2 years than their counterparts. Methods: We conducted a retrospective analysis of women who delivered child(ren) vaginally between 1996 and 2008. Women were identified as those who received intrapartum antibiotics and those who did not. Pediatric records were used to determine the incidence of AD. Results: We collected data for 492 mother- child pairs. Intrapartum antibiotics were administered during 128 births; 28.9{\%} of those children were diagnosed with AD by age 2 years (relative risk [RR], 1.03; 95{\%} confidence interval [CI], 0.75-1.41). Factors with the greatest risk of diagnosis of AD by 2 years of age were intrapartum antibiotic exposure for >24 hours (RR, 1.99; 95{\%} CI, 1.13-3.49), first born (RR, 1.78; 95{\%} CI, 1.33-2.38), and higher maternal education (RR, 1.43; 95{\%} CI, 0.99 -2.06). No statistical differences in the prevalence of AD related to parental eczema, maternal group B Streptococcus status, or gestational age existed. Conclusions: Exposure to antibiotics for <24 hours during a vaginal delivery does not increase the risk of AD. Studies are needed to understand whether exposure for >24 hours during the intrapartum period increases the risk of AD.",
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Intrapartum antibiotics and childhood atopic dermatitis. / Wohl, Debra L.; Curry, William J.; Mauger, Dave; Miller, Jennifer; Tyrie, Kaitlyn.

In: Journal of the American Board of Family Medicine, Vol. 28, No. 1, 01.01.2015, p. 82-89.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Intrapartum antibiotics and childhood atopic dermatitis

AU - Wohl, Debra L.

AU - Curry, William J.

AU - Mauger, Dave

AU - Miller, Jennifer

AU - Tyrie, Kaitlyn

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Introduction: Atopic dermatitis (AD) in children significantly impacts families because of medical costs, "lost" hours, and secondary characteristics such as asthma and ancillary infections. We investigate whether children delivered vaginally to women receiving intrapartum antibiotics have a greater risk of AD when younger than the age of 2 years than their counterparts. Methods: We conducted a retrospective analysis of women who delivered child(ren) vaginally between 1996 and 2008. Women were identified as those who received intrapartum antibiotics and those who did not. Pediatric records were used to determine the incidence of AD. Results: We collected data for 492 mother- child pairs. Intrapartum antibiotics were administered during 128 births; 28.9% of those children were diagnosed with AD by age 2 years (relative risk [RR], 1.03; 95% confidence interval [CI], 0.75-1.41). Factors with the greatest risk of diagnosis of AD by 2 years of age were intrapartum antibiotic exposure for >24 hours (RR, 1.99; 95% CI, 1.13-3.49), first born (RR, 1.78; 95% CI, 1.33-2.38), and higher maternal education (RR, 1.43; 95% CI, 0.99 -2.06). No statistical differences in the prevalence of AD related to parental eczema, maternal group B Streptococcus status, or gestational age existed. Conclusions: Exposure to antibiotics for <24 hours during a vaginal delivery does not increase the risk of AD. Studies are needed to understand whether exposure for >24 hours during the intrapartum period increases the risk of AD.

AB - Introduction: Atopic dermatitis (AD) in children significantly impacts families because of medical costs, "lost" hours, and secondary characteristics such as asthma and ancillary infections. We investigate whether children delivered vaginally to women receiving intrapartum antibiotics have a greater risk of AD when younger than the age of 2 years than their counterparts. Methods: We conducted a retrospective analysis of women who delivered child(ren) vaginally between 1996 and 2008. Women were identified as those who received intrapartum antibiotics and those who did not. Pediatric records were used to determine the incidence of AD. Results: We collected data for 492 mother- child pairs. Intrapartum antibiotics were administered during 128 births; 28.9% of those children were diagnosed with AD by age 2 years (relative risk [RR], 1.03; 95% confidence interval [CI], 0.75-1.41). Factors with the greatest risk of diagnosis of AD by 2 years of age were intrapartum antibiotic exposure for >24 hours (RR, 1.99; 95% CI, 1.13-3.49), first born (RR, 1.78; 95% CI, 1.33-2.38), and higher maternal education (RR, 1.43; 95% CI, 0.99 -2.06). No statistical differences in the prevalence of AD related to parental eczema, maternal group B Streptococcus status, or gestational age existed. Conclusions: Exposure to antibiotics for <24 hours during a vaginal delivery does not increase the risk of AD. Studies are needed to understand whether exposure for >24 hours during the intrapartum period increases the risk of AD.

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