Intrathecal ketorolac tromethamine produces analgesia after chronic constriction iniury of sciatic nerve in rat

W. C.V. Parris, P. K. Janicki, B. Johnson, J. L. Horn

Research output: Contribution to journalArticle

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Abstract

Purpose: The study compared analgesic efficacy of intrathecally administered ketorolac tromethamine (K) and morphine hydrochloride (M) (in equimolar doses) in the chronic neuropathic pain model, induced by chronic constriction injury (CCI) of the sciatic nerve in rat. Methods: Male Sprague-Dawley rats (n = 30) were anaesthetized with halothane and an intrathecal catheter was inserted to the mid-lumbar level of the spinal cord. On the 5th postoperative day, rats were anaesthetized with halothane and four ligatures were loosely applied around the right sciatic nerve. Seven days later, those animals were randomly divided into three groups and were injected with either saline, M (20 nmoles) or K (20 nmoles). Two pain responses (foot-withdrawal delay and hind paw elevation time) were measured on both sides using the radiant heat method. Further, thermal ('cold') allodynia was assessed by measuring of the total time of hind paw elevation in animals placed on the cold metal plate. Results: Twenty nmoles of M and K injected intrathecally produced decrease of differential pain score calculated for both measured responses (hind paw withdrawal and hind paw elevation), compared with saline injected animals (P < 0.05). The reduction in pain response produced by K was less (P < 0.05) than the reduction in pain response observed in the animals receiving intrathecal M. Measurement of cold allodynia revealed that the animals in M and K injected groups demonstrated decreases in the total hind paw elevation time, when compared with saline-injected animals (P < 0.05). Conclusion: M and K produced hypoalgesia after intrathecal administration in rats with CCI, with M being more potent than K at an equimolar dose range. The analgesic effect of K was equal to equimolar doses of M for alleviation of cold allodynia.

Original languageEnglish (US)
Pages (from-to)867-870
Number of pages4
JournalCanadian Journal of Anaesthesia
Volume43
Issue number8
DOIs
StatePublished - Aug 1996

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Ketorolac Tromethamine
Sciatic Nerve
Constriction
Analgesia
Hyperalgesia
Pain
Halothane
Analgesics
Wounds and Injuries
Neuralgia
Chronic Pain
Morphine
Ligation
Sprague Dawley Rats
Foot
Spinal Cord
Catheters
Hot Temperature
Metals

All Science Journal Classification (ASJC) codes

  • Anesthesiology and Pain Medicine

Cite this

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title = "Intrathecal ketorolac tromethamine produces analgesia after chronic constriction iniury of sciatic nerve in rat",
abstract = "Purpose: The study compared analgesic efficacy of intrathecally administered ketorolac tromethamine (K) and morphine hydrochloride (M) (in equimolar doses) in the chronic neuropathic pain model, induced by chronic constriction injury (CCI) of the sciatic nerve in rat. Methods: Male Sprague-Dawley rats (n = 30) were anaesthetized with halothane and an intrathecal catheter was inserted to the mid-lumbar level of the spinal cord. On the 5th postoperative day, rats were anaesthetized with halothane and four ligatures were loosely applied around the right sciatic nerve. Seven days later, those animals were randomly divided into three groups and were injected with either saline, M (20 nmoles) or K (20 nmoles). Two pain responses (foot-withdrawal delay and hind paw elevation time) were measured on both sides using the radiant heat method. Further, thermal ('cold') allodynia was assessed by measuring of the total time of hind paw elevation in animals placed on the cold metal plate. Results: Twenty nmoles of M and K injected intrathecally produced decrease of differential pain score calculated for both measured responses (hind paw withdrawal and hind paw elevation), compared with saline injected animals (P < 0.05). The reduction in pain response produced by K was less (P < 0.05) than the reduction in pain response observed in the animals receiving intrathecal M. Measurement of cold allodynia revealed that the animals in M and K injected groups demonstrated decreases in the total hind paw elevation time, when compared with saline-injected animals (P < 0.05). Conclusion: M and K produced hypoalgesia after intrathecal administration in rats with CCI, with M being more potent than K at an equimolar dose range. The analgesic effect of K was equal to equimolar doses of M for alleviation of cold allodynia.",
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Intrathecal ketorolac tromethamine produces analgesia after chronic constriction iniury of sciatic nerve in rat. / Parris, W. C.V.; Janicki, P. K.; Johnson, B.; Horn, J. L.

In: Canadian Journal of Anaesthesia, Vol. 43, No. 8, 08.1996, p. 867-870.

Research output: Contribution to journalArticle

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