Intrathecal methiothepin and thyrotropin-releasing hormone effects on penile erection

Gregory Holmes, Robert L. Stephens, Jacqueline C. Bresnahan, Michael S. Beattie

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Intrathecal thyrotropin-releasing hormone (TRH) potently inhibits penile erection at all doses (100, 500, 1000 or 5000 pmol) tested so far. Since the serotonin receptor antagonist methiothepin (MT) inhibits TRH responses in other systems, this study tested the hypothesis that MT-sensitive receptors mediate the effect of TRH on penile erection in rats. When compared to controls, the highest doses of IT TRH (0, 10 or 500 pmol) or MT (5 or 50 nmol) significantly altered penile reflex latency. When coadministered (50 nmol MT/500 pmol TRH), the effect of TRH was reversed, suggesting that the high dose of MT antagonized the inhibitory actions of TRH. The low dose of MT (5 nmol) did not block the 500 pmol TRH inhibition of reflex latency. These data further suggest that MT sensitive receptors are important in (1) mediating normal penile reflexes and (2) mediating the inhibitory response to TRH.

Original languageEnglish (US)
Pages (from-to)59-64
Number of pages6
JournalPhysiology and Behavior
Volume73
Issue number1-2
DOIs
StatePublished - Jan 1 2001

Fingerprint

Methiothepin
Penile Erection
Thyrotropin-Releasing Hormone
Reflex
Serotonin Antagonists

All Science Journal Classification (ASJC) codes

  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience

Cite this

Holmes, Gregory ; Stephens, Robert L. ; Bresnahan, Jacqueline C. ; Beattie, Michael S. / Intrathecal methiothepin and thyrotropin-releasing hormone effects on penile erection. In: Physiology and Behavior. 2001 ; Vol. 73, No. 1-2. pp. 59-64.
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Intrathecal methiothepin and thyrotropin-releasing hormone effects on penile erection. / Holmes, Gregory; Stephens, Robert L.; Bresnahan, Jacqueline C.; Beattie, Michael S.

In: Physiology and Behavior, Vol. 73, No. 1-2, 01.01.2001, p. 59-64.

Research output: Contribution to journalArticle

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