Intrathecal serotonin attenuates the pressor response to static contraction

Janeen M. Hill, Marc P. Kaufman

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Abstract

We tested the hypothesis that intrathecal injection of serotonin onto the lumbosacral spinal cord of chloralose-anesthetized cats attenuates the pressor response to static contraction of the triceps surae muscles. Serotonin (10 μg) significantly attenuated the contraction-induced reflex increases in mean arterial pressure but not in ventilation. This attenuation of the reflex pressor response to static contraction by serotonin was prevented by prior intrathecal injection of mianserin hydrochloride, a serotonergic receptor antagonist. In addition, the reflex pressor response to contraction was significantly attenuated by intrathecal injection of carnoxamidotryptamine maleate, a 5-HT1 agonist but not by DOI-hydrochloride, a 5-HT2 agonist. We conclude that stimulation of 5-HT1 receptors in the lumbosacral spinal cord attenuates the reflex pressor response to static muscular contraction.

Original languageEnglish (US)
Pages (from-to)157-160
Number of pages4
JournalBrain research
Volume550
Issue number1
DOIs
Publication statusPublished - May 31 1991

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All Science Journal Classification (ASJC) codes

  • Neuroscience(all)
  • Molecular Biology
  • Clinical Neurology
  • Developmental Biology

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