Intravascular thrombosis: Definitive detection by quantitative tissue characterization in vitro

Benico Barzilai, Howard Eisen

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

To improve the sensitivity and reliability of the ultraasonic detection of intravascular thrombosis, we employed quantitative ultrasonic techniques for the analysis of thrombi induced in vitro. Citrated human blood or platelet‐rich plasma was added to sections of canine thoracic aorta mounted vertically in a saline bath. CaCl2 and thrombin were then added to induce thrombosis. Ultrasonic integrated backscatter measured sequentially with a 10‐MHz focused transducer exhibited more than a 10 dB increase in integrated backscatter when either whole blood or plateletrich plasma was clotted (−61.7 dB to −47.4 dB whole blood; < −70 dB to −52.8 dB platelet‐rich plasma). Thus, large significant changes in integrated backscatter measured from structures within the arterial lumen were readily detectable and indicative of thrombosis in situ.

Original languageEnglish (US)
Pages (from-to)579-584
Number of pages6
JournalJournal of Clinical Ultrasound
Volume17
Issue number8
DOIs
StatePublished - Jan 1 1989

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Thrombosis
Ultrasonics
Transducers
Thoracic Aorta
Baths
Thrombin
Canidae
In Vitro Techniques

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

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abstract = "To improve the sensitivity and reliability of the ultraasonic detection of intravascular thrombosis, we employed quantitative ultrasonic techniques for the analysis of thrombi induced in vitro. Citrated human blood or platelet‐rich plasma was added to sections of canine thoracic aorta mounted vertically in a saline bath. CaCl2 and thrombin were then added to induce thrombosis. Ultrasonic integrated backscatter measured sequentially with a 10‐MHz focused transducer exhibited more than a 10 dB increase in integrated backscatter when either whole blood or plateletrich plasma was clotted (−61.7 dB to −47.4 dB whole blood; < −70 dB to −52.8 dB platelet‐rich plasma). Thus, large significant changes in integrated backscatter measured from structures within the arterial lumen were readily detectable and indicative of thrombosis in situ.",
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Intravascular thrombosis : Definitive detection by quantitative tissue characterization in vitro. / Barzilai, Benico; Eisen, Howard.

In: Journal of Clinical Ultrasound, Vol. 17, No. 8, 01.01.1989, p. 579-584.

Research output: Contribution to journalArticle

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