Intraventricular gliomas

Aaron S. Dumont, Elana Farace, David Schiff, Mark E. Shaffrey

Research output: Contribution to journalReview articlepeer-review

10 Scopus citations

Abstract

Gliomas are the most common primary brain tumor in adults, and those within or relating to the ventricular surface represent a less common but important subcategory. The most common intraventricular gliomas include ependymomas, SEs, and SEGAs. Other less common varieties have been reported, including chordoid gliomas, glioblastoma multiforme, and mixed glial-neuronal tumors. Each type of intraventricular glioma is associated with its own unique constellation of epidemiologic, clinical, radiologic, and pathologic defining characteristics. Each tumor type has its own management considerations and nuances with unique prognostic indicators and outcomes. The outcome for certain intraventricular gliomas (especially ependymomas) remains relatively poor. Future advancements in surgical technique are likely to have only a modest impact on improvement of outcome. Translational research aiming to advance the knowledge of tumor biology into new targeted cellular and molecular therapies holds tremendous promise to improve the overall outcome. Additionally, more thorough delineation of prognostic factors as well as modifications and refinements to radiation and chemotherapy may help to improve the still significantly poor outcomes for patients harboring these lesions. Future cooperative intra- and interinstitutional efforts between scientists and clinicians will hopefully culminate in an improved outlook and eventual cure for patients with gliomas.

Original languageEnglish (US)
Pages (from-to)571-591
Number of pages21
JournalNeurosurgery clinics of North America
Volume14
Issue number4
DOIs
StatePublished - Oct 2003

All Science Journal Classification (ASJC) codes

  • Surgery
  • Clinical Neurology

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