Abstract
Pigment epithelium-derived factor (PEDF), a serpin-like protein, is claimed to be a neurotropic factor and a potent inhibitor of intraocular angiogenesis. We quantitated the intravitreal level of PEDF in 23 eyes that received vitreous surgery using enzyme-linked immunosorbent assay (ELISA). The series comprised proliferative diabetic retinopathy 8 eyes, rhegmatogenous retinal detachment 7 eyes, idiopathic macular hole 4 eyes and others. The concentration of PEDF averaged 0.37 ± 0.13 μg/ml in diabetic retinopathy, 3.53 ± 0.85 μg/ml in retinal detachment and 1.76 ± 0.85 μg/ml in macular hole. Its value in macular hole was similar to the normal level. Its lower levels in proliferative diabetic retinopathy seemed to show decreased inhibitory effect for intraocular angiogenesis. Its increased levels in rhegmatogenous retinal detachment seemed to show a neuroprotective role for the detached retina.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1077-1079 |
| Number of pages | 3 |
| Journal | Japanese Journal of Clinical Ophthalmology |
| Volume | 55 |
| Issue number | 6 |
| State | Published - Jan 1 2001 |
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All Science Journal Classification (ASJC) codes
- Ophthalmology
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Intravitreal level of pigment epithelium-derived factor (PEDF). / Ogata, N.; Nishimura, T.; Tombran-Tink, Joyce; Matsumura, M.
In: Japanese Journal of Clinical Ophthalmology, Vol. 55, No. 6, 01.01.2001, p. 1077-1079.Research output: Contribution to journal › Article
TY - JOUR
T1 - Intravitreal level of pigment epithelium-derived factor (PEDF)
AU - Ogata, N.
AU - Nishimura, T.
AU - Tombran-Tink, Joyce
AU - Matsumura, M.
PY - 2001/1/1
Y1 - 2001/1/1
N2 - Pigment epithelium-derived factor (PEDF), a serpin-like protein, is claimed to be a neurotropic factor and a potent inhibitor of intraocular angiogenesis. We quantitated the intravitreal level of PEDF in 23 eyes that received vitreous surgery using enzyme-linked immunosorbent assay (ELISA). The series comprised proliferative diabetic retinopathy 8 eyes, rhegmatogenous retinal detachment 7 eyes, idiopathic macular hole 4 eyes and others. The concentration of PEDF averaged 0.37 ± 0.13 μg/ml in diabetic retinopathy, 3.53 ± 0.85 μg/ml in retinal detachment and 1.76 ± 0.85 μg/ml in macular hole. Its value in macular hole was similar to the normal level. Its lower levels in proliferative diabetic retinopathy seemed to show decreased inhibitory effect for intraocular angiogenesis. Its increased levels in rhegmatogenous retinal detachment seemed to show a neuroprotective role for the detached retina.
AB - Pigment epithelium-derived factor (PEDF), a serpin-like protein, is claimed to be a neurotropic factor and a potent inhibitor of intraocular angiogenesis. We quantitated the intravitreal level of PEDF in 23 eyes that received vitreous surgery using enzyme-linked immunosorbent assay (ELISA). The series comprised proliferative diabetic retinopathy 8 eyes, rhegmatogenous retinal detachment 7 eyes, idiopathic macular hole 4 eyes and others. The concentration of PEDF averaged 0.37 ± 0.13 μg/ml in diabetic retinopathy, 3.53 ± 0.85 μg/ml in retinal detachment and 1.76 ± 0.85 μg/ml in macular hole. Its value in macular hole was similar to the normal level. Its lower levels in proliferative diabetic retinopathy seemed to show decreased inhibitory effect for intraocular angiogenesis. Its increased levels in rhegmatogenous retinal detachment seemed to show a neuroprotective role for the detached retina.
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UR - http://www.scopus.com/inward/citedby.url?scp=0034921872&partnerID=8YFLogxK
M3 - Article
AN - SCOPUS:0034921872
VL - 55
SP - 1077
EP - 1079
JO - Japanese Journal of Clinical Ophthalmology
JF - Japanese Journal of Clinical Ophthalmology
SN - 0370-5579
IS - 6
ER -