Intravitreal level of pigment epithelium-derived factor (PEDF)

N. Ogata, T. Nishimura, Joyce Tombran-Tink, M. Matsumura

Research output: Contribution to journalArticle

Abstract

Pigment epithelium-derived factor (PEDF), a serpin-like protein, is claimed to be a neurotropic factor and a potent inhibitor of intraocular angiogenesis. We quantitated the intravitreal level of PEDF in 23 eyes that received vitreous surgery using enzyme-linked immunosorbent assay (ELISA). The series comprised proliferative diabetic retinopathy 8 eyes, rhegmatogenous retinal detachment 7 eyes, idiopathic macular hole 4 eyes and others. The concentration of PEDF averaged 0.37 ± 0.13 μg/ml in diabetic retinopathy, 3.53 ± 0.85 μg/ml in retinal detachment and 1.76 ± 0.85 μg/ml in macular hole. Its value in macular hole was similar to the normal level. Its lower levels in proliferative diabetic retinopathy seemed to show decreased inhibitory effect for intraocular angiogenesis. Its increased levels in rhegmatogenous retinal detachment seemed to show a neuroprotective role for the detached retina.

Original languageEnglish (US)
Pages (from-to)1077-1079
Number of pages3
JournalJapanese Journal of Clinical Ophthalmology
Volume55
Issue number6
StatePublished - Jan 1 2001

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Retinal Perforations
Retinal Detachment
Diabetic Retinopathy
Serpins
Angiogenesis Inhibitors
Retina
Enzyme-Linked Immunosorbent Assay
pigment epithelium-derived factor
Proteins

All Science Journal Classification (ASJC) codes

  • Ophthalmology

Cite this

Ogata, N. ; Nishimura, T. ; Tombran-Tink, Joyce ; Matsumura, M. / Intravitreal level of pigment epithelium-derived factor (PEDF). In: Japanese Journal of Clinical Ophthalmology. 2001 ; Vol. 55, No. 6. pp. 1077-1079.
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Intravitreal level of pigment epithelium-derived factor (PEDF). / Ogata, N.; Nishimura, T.; Tombran-Tink, Joyce; Matsumura, M.

In: Japanese Journal of Clinical Ophthalmology, Vol. 55, No. 6, 01.01.2001, p. 1077-1079.

Research output: Contribution to journalArticle

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