Intricacies in ATP-dependent clamp loading: Variations across replication systems

M. A. Trakselis, Stephen Benkovic

Research output: Contribution to journalReview article

24 Citations (Scopus)

Abstract

DNA replication requires the coordinated effort of many proteins to create a highly processive biomachine able to replicate entire genomes in a single process. The clamp proteins confer on replisomes this property of processivity but in turn require clamp loaders for their functional assembly onto DNA. A more detailed view of the mechanisms for holoenzyme assembly in replication systems has been obtained from the advent of novel solution experiments and the appearance of low- and high-resolution structures for the clamp loaders.

Original languageEnglish (US)
Pages (from-to)999-1004
Number of pages6
JournalStructure
Volume9
Issue number11
DOIs
StatePublished - Jan 1 2001

Fingerprint

Adenosine Triphosphate
Holoenzymes
DNA Replication
Proteins
Genome
DNA

All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Molecular Biology

Cite this

Trakselis, M. A. ; Benkovic, Stephen. / Intricacies in ATP-dependent clamp loading : Variations across replication systems. In: Structure. 2001 ; Vol. 9, No. 11. pp. 999-1004.
@article{d28945ae0f07441683acd87ec113bf85,
title = "Intricacies in ATP-dependent clamp loading: Variations across replication systems",
abstract = "DNA replication requires the coordinated effort of many proteins to create a highly processive biomachine able to replicate entire genomes in a single process. The clamp proteins confer on replisomes this property of processivity but in turn require clamp loaders for their functional assembly onto DNA. A more detailed view of the mechanisms for holoenzyme assembly in replication systems has been obtained from the advent of novel solution experiments and the appearance of low- and high-resolution structures for the clamp loaders.",
author = "Trakselis, {M. A.} and Stephen Benkovic",
year = "2001",
month = "1",
day = "1",
doi = "10.1016/S0969-2126(01)00676-1",
language = "English (US)",
volume = "9",
pages = "999--1004",
journal = "Structure with Folding & design",
issn = "0969-2126",
publisher = "Cell Press",
number = "11",

}

Intricacies in ATP-dependent clamp loading : Variations across replication systems. / Trakselis, M. A.; Benkovic, Stephen.

In: Structure, Vol. 9, No. 11, 01.01.2001, p. 999-1004.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Intricacies in ATP-dependent clamp loading

T2 - Variations across replication systems

AU - Trakselis, M. A.

AU - Benkovic, Stephen

PY - 2001/1/1

Y1 - 2001/1/1

N2 - DNA replication requires the coordinated effort of many proteins to create a highly processive biomachine able to replicate entire genomes in a single process. The clamp proteins confer on replisomes this property of processivity but in turn require clamp loaders for their functional assembly onto DNA. A more detailed view of the mechanisms for holoenzyme assembly in replication systems has been obtained from the advent of novel solution experiments and the appearance of low- and high-resolution structures for the clamp loaders.

AB - DNA replication requires the coordinated effort of many proteins to create a highly processive biomachine able to replicate entire genomes in a single process. The clamp proteins confer on replisomes this property of processivity but in turn require clamp loaders for their functional assembly onto DNA. A more detailed view of the mechanisms for holoenzyme assembly in replication systems has been obtained from the advent of novel solution experiments and the appearance of low- and high-resolution structures for the clamp loaders.

UR - http://www.scopus.com/inward/record.url?scp=0035179213&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0035179213&partnerID=8YFLogxK

U2 - 10.1016/S0969-2126(01)00676-1

DO - 10.1016/S0969-2126(01)00676-1

M3 - Review article

C2 - 11709164

AN - SCOPUS:0035179213

VL - 9

SP - 999

EP - 1004

JO - Structure with Folding & design

JF - Structure with Folding & design

SN - 0969-2126

IS - 11

ER -