Introduction to the thematic minireview series: Sixty plus years of polyamine research

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Polyamines have a long history in biochemistry and physiology, dating back to 1678 when Leeuwenhoek first reported crystals that were composed of spermine phosphate in seminal fluid. Their quantification and biosynthetic pathway were first described by Herb and Celia Tabor in collaboration with Sanford Rosenthal in the late 1950s. This work led to immense interest in their physiological functions. The 11 Minireviews in this collection illustrate many of the wide-ranging biochemical effects of the polyamines. This series provides a fitting tribute to Herb Tabor on the occasion of his 100th birthday, demonstrating clearly the importance and growth of the research field that he pioneered in the late 1950s and has contributed to for many years. His studies of the synthesis, function, and toxicity of polyamines have yielded multiple insights into fundamental biochemical processes and formed the basis of successful and continuing drug development. This Minireview series reviews the highly diverse properties of polyamines in bacteria, protozoa, and mammals, highlighting the importance of these molecules in growth, development, and response to the environment, and their involvement in diseases, including cancer, and those caused by parasitic protozoans.

Original languageEnglish (US)
Pages (from-to)18681-18692
Number of pages12
JournalJournal of Biological Chemistry
Volume293
Issue number48
DOIs
StatePublished - Jan 1 2018

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Polyamines
Research
Biochemical Phenomena
Protozoa
Biochemistry
Mammals
Spermine
Biosynthetic Pathways
Physiology
Growth and Development
Toxicity
Bacteria
History
Phosphates
Crystals
Molecules
Fluids
Growth
Pharmaceutical Preparations
Neoplasms

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

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Introduction to the thematic minireview series : Sixty plus years of polyamine research. / Pegg, Anthony E.

In: Journal of Biological Chemistry, Vol. 293, No. 48, 01.01.2018, p. 18681-18692.

Research output: Contribution to journalReview article

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