Invasive Cancers Detected after Breast Cancer Screening Yielded a Negative Result

Relationship of Mammographic Density to Tumor Prognostic Factors

Marilyn A. Roubidoux, Janet E. Bailey, Linda Ann Wray, Mark A. Helvie

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

PURPOSE: To evaluate common breast tumor prognostic characteristics, including estrogen receptor (ER) status, grade, size, and method of detection, in relationship to mammographic density. MATERIALS AND METHODS: The study involved 121 women who had negative results at both screening mammography and breast physical examination within 17 months before a diagnosis of breast cancer. Mammographic density was classified according to Breast Imaging Reporting and Data System patterns 1 through 4 (where 1 indicates a fatty breast and 4 indicates a dense breast). Axillary nodal status and tumor histologic ER status, histologic grade, size, stage, and method of detection (mammography alone, palpation alone, or both palpation and mammography) were analyzed by density category and tested for statistically significant differences across categories by using analysis of variance. RESULTS: Statistically significant differences (P < .05) by density category were found for the following variables: ER positivity (15 of 15 tumors in category 1 breasts, 32 of 41 tumors in category 2 breasts, 37 of 49 tumors in category 3 breasts, and eight of 16 tumors in category 4 breasts were ER positive), occurrence of grade 1 tumors (eight, 11, 19, and four tumors in category 1, category 2, category 3, and category 4 breasts, respectively, were grade 1), mean tumor size (11.3, 13.0, 14.7, and 19.7 mm for category 1, category 2, category 3, and category 4 breasts, respectively), detection with mammography alone (13, 31, 36, and four tumors in category 1, category 2, category 3, and category 4 breasts, respectively, were detected with mammography alone), and occurrence of stage I tumors (10, 25, 28, and five tumors in category 1, category 2, category 3, and category 4 breasts, respectively, were stage I). CONCLUSION: In women with negative results at clinical and mammographic screening within 17 months before breast tumor detection, subsequently diagnosed cancers tend to be ER negative, of higher grade, and larger in size in those with dense tissue patterns than in those with fat patterns.

Original languageEnglish (US)
Pages (from-to)42-48
Number of pages7
JournalRadiology
Volume230
Issue number1
DOIs
StatePublished - Jan 1 2004

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Early Detection of Cancer
Breast
Breast Neoplasms
Mammography
Neoplasms
Estrogen Receptors
Palpation
Breast Density
Information Systems
Physical Examination
Analysis of Variance
Fats

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

@article{3635dfa1de32485a88e14f80c6221614,
title = "Invasive Cancers Detected after Breast Cancer Screening Yielded a Negative Result: Relationship of Mammographic Density to Tumor Prognostic Factors",
abstract = "PURPOSE: To evaluate common breast tumor prognostic characteristics, including estrogen receptor (ER) status, grade, size, and method of detection, in relationship to mammographic density. MATERIALS AND METHODS: The study involved 121 women who had negative results at both screening mammography and breast physical examination within 17 months before a diagnosis of breast cancer. Mammographic density was classified according to Breast Imaging Reporting and Data System patterns 1 through 4 (where 1 indicates a fatty breast and 4 indicates a dense breast). Axillary nodal status and tumor histologic ER status, histologic grade, size, stage, and method of detection (mammography alone, palpation alone, or both palpation and mammography) were analyzed by density category and tested for statistically significant differences across categories by using analysis of variance. RESULTS: Statistically significant differences (P < .05) by density category were found for the following variables: ER positivity (15 of 15 tumors in category 1 breasts, 32 of 41 tumors in category 2 breasts, 37 of 49 tumors in category 3 breasts, and eight of 16 tumors in category 4 breasts were ER positive), occurrence of grade 1 tumors (eight, 11, 19, and four tumors in category 1, category 2, category 3, and category 4 breasts, respectively, were grade 1), mean tumor size (11.3, 13.0, 14.7, and 19.7 mm for category 1, category 2, category 3, and category 4 breasts, respectively), detection with mammography alone (13, 31, 36, and four tumors in category 1, category 2, category 3, and category 4 breasts, respectively, were detected with mammography alone), and occurrence of stage I tumors (10, 25, 28, and five tumors in category 1, category 2, category 3, and category 4 breasts, respectively, were stage I). CONCLUSION: In women with negative results at clinical and mammographic screening within 17 months before breast tumor detection, subsequently diagnosed cancers tend to be ER negative, of higher grade, and larger in size in those with dense tissue patterns than in those with fat patterns.",
author = "Roubidoux, {Marilyn A.} and Bailey, {Janet E.} and Wray, {Linda Ann} and Helvie, {Mark A.}",
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Invasive Cancers Detected after Breast Cancer Screening Yielded a Negative Result : Relationship of Mammographic Density to Tumor Prognostic Factors. / Roubidoux, Marilyn A.; Bailey, Janet E.; Wray, Linda Ann; Helvie, Mark A.

In: Radiology, Vol. 230, No. 1, 01.01.2004, p. 42-48.

Research output: Contribution to journalArticle

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T1 - Invasive Cancers Detected after Breast Cancer Screening Yielded a Negative Result

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N2 - PURPOSE: To evaluate common breast tumor prognostic characteristics, including estrogen receptor (ER) status, grade, size, and method of detection, in relationship to mammographic density. MATERIALS AND METHODS: The study involved 121 women who had negative results at both screening mammography and breast physical examination within 17 months before a diagnosis of breast cancer. Mammographic density was classified according to Breast Imaging Reporting and Data System patterns 1 through 4 (where 1 indicates a fatty breast and 4 indicates a dense breast). Axillary nodal status and tumor histologic ER status, histologic grade, size, stage, and method of detection (mammography alone, palpation alone, or both palpation and mammography) were analyzed by density category and tested for statistically significant differences across categories by using analysis of variance. RESULTS: Statistically significant differences (P < .05) by density category were found for the following variables: ER positivity (15 of 15 tumors in category 1 breasts, 32 of 41 tumors in category 2 breasts, 37 of 49 tumors in category 3 breasts, and eight of 16 tumors in category 4 breasts were ER positive), occurrence of grade 1 tumors (eight, 11, 19, and four tumors in category 1, category 2, category 3, and category 4 breasts, respectively, were grade 1), mean tumor size (11.3, 13.0, 14.7, and 19.7 mm for category 1, category 2, category 3, and category 4 breasts, respectively), detection with mammography alone (13, 31, 36, and four tumors in category 1, category 2, category 3, and category 4 breasts, respectively, were detected with mammography alone), and occurrence of stage I tumors (10, 25, 28, and five tumors in category 1, category 2, category 3, and category 4 breasts, respectively, were stage I). CONCLUSION: In women with negative results at clinical and mammographic screening within 17 months before breast tumor detection, subsequently diagnosed cancers tend to be ER negative, of higher grade, and larger in size in those with dense tissue patterns than in those with fat patterns.

AB - PURPOSE: To evaluate common breast tumor prognostic characteristics, including estrogen receptor (ER) status, grade, size, and method of detection, in relationship to mammographic density. MATERIALS AND METHODS: The study involved 121 women who had negative results at both screening mammography and breast physical examination within 17 months before a diagnosis of breast cancer. Mammographic density was classified according to Breast Imaging Reporting and Data System patterns 1 through 4 (where 1 indicates a fatty breast and 4 indicates a dense breast). Axillary nodal status and tumor histologic ER status, histologic grade, size, stage, and method of detection (mammography alone, palpation alone, or both palpation and mammography) were analyzed by density category and tested for statistically significant differences across categories by using analysis of variance. RESULTS: Statistically significant differences (P < .05) by density category were found for the following variables: ER positivity (15 of 15 tumors in category 1 breasts, 32 of 41 tumors in category 2 breasts, 37 of 49 tumors in category 3 breasts, and eight of 16 tumors in category 4 breasts were ER positive), occurrence of grade 1 tumors (eight, 11, 19, and four tumors in category 1, category 2, category 3, and category 4 breasts, respectively, were grade 1), mean tumor size (11.3, 13.0, 14.7, and 19.7 mm for category 1, category 2, category 3, and category 4 breasts, respectively), detection with mammography alone (13, 31, 36, and four tumors in category 1, category 2, category 3, and category 4 breasts, respectively, were detected with mammography alone), and occurrence of stage I tumors (10, 25, 28, and five tumors in category 1, category 2, category 3, and category 4 breasts, respectively, were stage I). CONCLUSION: In women with negative results at clinical and mammographic screening within 17 months before breast tumor detection, subsequently diagnosed cancers tend to be ER negative, of higher grade, and larger in size in those with dense tissue patterns than in those with fat patterns.

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