Investigation into the mechanisms of tissue atomization by high-intensity focused ultrasound

Julianna Simon, Oleg A. Sapozhnikov, Yak Nam Wang, Vera A. Khokhlova, Lawrence A. Crum, Michael R. Bailey

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Ultrasonic atomization, or the emission of a fog of droplets, was recently proposed to explain tissue fractionation in boiling histotripsy. However, even though liquid atomization has been studied extensively, the mechanisms underlying tissue atomization remain unclear. In the work described here, high-speed photography and overpressure were used to evaluate the role of bubbles in tissue atomization. As static pressure increased, the degree of fractionation decreased, and the exvivo tissue became thermally denatured. The effect of surface wetness on atomization was also evaluated invivo and in tissue-mimicking gels, where surface wetness was found to enhance atomization by forming surface instabilities that augment cavitation. In addition, experimental results indicated that wetting collagenous tissues, such as the liver capsule, allowed atomization to breach such barriers. These results highlight the importance of bubbles and surface instabilities in atomization and could be used to enhance boiling histotripsy for transition to clinical use.

Original languageEnglish (US)
Pages (from-to)1372-1385
Number of pages14
JournalUltrasound in Medicine and Biology
Volume41
Issue number5
DOIs
StatePublished - May 1 2015

Fingerprint

atomizing
fractionation
boiling
moisture content
liquid atomization
bubbles
Photography
Weather
high speed photography
fog
overpressure
static pressure
Ultrasonics
capsules
Capsules
cavitation flow
liver
wetting
Gels
ultrasonics

All Science Journal Classification (ASJC) codes

  • Radiological and Ultrasound Technology
  • Biophysics
  • Radiology Nuclear Medicine and imaging

Cite this

Simon, Julianna ; Sapozhnikov, Oleg A. ; Wang, Yak Nam ; Khokhlova, Vera A. ; Crum, Lawrence A. ; Bailey, Michael R. / Investigation into the mechanisms of tissue atomization by high-intensity focused ultrasound. In: Ultrasound in Medicine and Biology. 2015 ; Vol. 41, No. 5. pp. 1372-1385.
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Investigation into the mechanisms of tissue atomization by high-intensity focused ultrasound. / Simon, Julianna; Sapozhnikov, Oleg A.; Wang, Yak Nam; Khokhlova, Vera A.; Crum, Lawrence A.; Bailey, Michael R.

In: Ultrasound in Medicine and Biology, Vol. 41, No. 5, 01.05.2015, p. 1372-1385.

Research output: Contribution to journalArticle

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