Investigation of an antibody-ligase. Evidence for strain-induced catalysis

Sergey N. Savinov, Ralph Hirschmann, Stephen J. Benkovic, Amos B. Smith

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Catalytic antibody 16G3, a peptide ligase with extended substrate scope has been characterized mechanistically exploiting a set of systematically designed perspective substrates 6-9, two of which, thioesters 8 and 9 act instead as inhibitors. Taken together the structure/activity relationships suggest a catalytic mechanism dependent on induction of strain, programmed via specific structural deviations between the hapten and the substrates. General mechanistic implications for de novo induced catalysis are presented.

Original languageEnglish (US)
Pages (from-to)1321-1324
Number of pages4
JournalBioorganic and Medicinal Chemistry Letters
Volume13
Issue number7
DOIs
StatePublished - Apr 7 2003

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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