Investigation of antimicrobial peptide salts: Efficacy and solubility in surfactant solutions for latex systems

Douglas A. Wicks, Alicyn Marie Rhoades, John S. Williamson, Bruhaspathy Miriyala

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Scopus citations

Abstract

The study and application of antimicrobial peptides is a growing niche field in the areas of pharmaceutics and medicinal chemistry. As a result, the majority of testing and development is completed under in vitro conditions. The use of synthetically derived antimicrobial peptides in applications outside the medical realm is a relatively untapped field, with the significance of interactions between antimicrobial oligopeptides and the ingredients of polymer systems being largely unknown. Water-based polymer coatings systems are attractive targets for microbial invasion because of their inherent material properties. Water-based polymer latex coatings contain a number of components which aide in stabilization and coalescence of the polymer particles, such as surfactants and polymeric cellulose-derived molecules, with several types of molecular structures existing for each, Microbes are able to flourish within the water phase of the latexes while taking sustenance from these dispersion components, resulting in a loss of properties commonly known as 'spoilage'. This work addresses the impact of formulation variables, specifically surfactant structure, on the solution and antimicrobial behavior of a model antimicrobial oligopeptides through the use of HT absorbance measurements.

Original languageEnglish (US)
Title of host publicationMaterials Research Society Symposium Proceedings
Pages139-146
Number of pages8
StatePublished - Jun 30 2006
EventCombinatorial Methods and Informatics in Materials Science - Boston, MA, United States
Duration: Nov 28 2005Dec 1 2005

Publication series

NameMaterials Research Society Symposium Proceedings
Volume894
ISSN (Print)0272-9172

Other

OtherCombinatorial Methods and Informatics in Materials Science
CountryUnited States
CityBoston, MA
Period11/28/0512/1/05

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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