Investigation of antimicrobial peptide salts

Efficacy and solubility in surfactant solutions for latex systems

Douglas A. Wicks, Alicyn Marie Rhoades, John S. Williamson, Bruhaspathy Miriyala

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

The study and application of antimicrobial peptides is a growing niche field in the areas of pharmaceutics and medicinal chemistry. As a result, the majority of testing and development is completed under in vitro conditions. The use of synthetically derived antimicrobial peptides in applications outside the medical realm is a relatively untapped field, with the significance of interactions between antimicrobial oligopeptides and the ingredients of polymer systems being largely unknown. Water-based polymer coatings systems are attractive targets for microbial invasion because of their inherent material properties. Water-based polymer latex coatings contain a number of components which aide in stabilization and coalescence of the polymer particles, such as surfactants and polymeric cellulose-derived molecules, with several types of molecular structures existing for each, Microbes are able to flourish within the water phase of the latexes while taking sustenance from these dispersion components, resulting in a loss of properties commonly known as 'spoilage'. This work addresses the impact of formulation variables, specifically surfactant structure, on the solution and antimicrobial behavior of a model antimicrobial oligopeptides through the use of HT absorbance measurements.

Original languageEnglish (US)
Title of host publicationMaterials Research Society Symposium Proceedings
Pages139-146
Number of pages8
Volume894
StatePublished - 2006
EventCombinatorial Methods and Informatics in Materials Science - Boston, MA, United States
Duration: Nov 28 2005Dec 1 2005

Other

OtherCombinatorial Methods and Informatics in Materials Science
CountryUnited States
CityBoston, MA
Period11/28/0512/1/05

Fingerprint

Latex
Latexes
Surface-Active Agents
Peptides
Polymers
Surface active agents
Solubility
Salts
Oligopeptides
Water
Spoilage
Coatings
Coalescence
Cellulose
Molecular structure
Particles (particulate matter)
Materials properties
Stabilization
Molecules
Testing

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials

Cite this

Wicks, D. A., Rhoades, A. M., Williamson, J. S., & Miriyala, B. (2006). Investigation of antimicrobial peptide salts: Efficacy and solubility in surfactant solutions for latex systems. In Materials Research Society Symposium Proceedings (Vol. 894, pp. 139-146)
Wicks, Douglas A. ; Rhoades, Alicyn Marie ; Williamson, John S. ; Miriyala, Bruhaspathy. / Investigation of antimicrobial peptide salts : Efficacy and solubility in surfactant solutions for latex systems. Materials Research Society Symposium Proceedings. Vol. 894 2006. pp. 139-146
@inproceedings{f44bf6b0421d48a19e2d4ecc051e9dd6,
title = "Investigation of antimicrobial peptide salts: Efficacy and solubility in surfactant solutions for latex systems",
abstract = "The study and application of antimicrobial peptides is a growing niche field in the areas of pharmaceutics and medicinal chemistry. As a result, the majority of testing and development is completed under in vitro conditions. The use of synthetically derived antimicrobial peptides in applications outside the medical realm is a relatively untapped field, with the significance of interactions between antimicrobial oligopeptides and the ingredients of polymer systems being largely unknown. Water-based polymer coatings systems are attractive targets for microbial invasion because of their inherent material properties. Water-based polymer latex coatings contain a number of components which aide in stabilization and coalescence of the polymer particles, such as surfactants and polymeric cellulose-derived molecules, with several types of molecular structures existing for each, Microbes are able to flourish within the water phase of the latexes while taking sustenance from these dispersion components, resulting in a loss of properties commonly known as 'spoilage'. This work addresses the impact of formulation variables, specifically surfactant structure, on the solution and antimicrobial behavior of a model antimicrobial oligopeptides through the use of HT absorbance measurements.",
author = "Wicks, {Douglas A.} and Rhoades, {Alicyn Marie} and Williamson, {John S.} and Bruhaspathy Miriyala",
year = "2006",
language = "English (US)",
isbn = "1558998489",
volume = "894",
pages = "139--146",
booktitle = "Materials Research Society Symposium Proceedings",

}

Wicks, DA, Rhoades, AM, Williamson, JS & Miriyala, B 2006, Investigation of antimicrobial peptide salts: Efficacy and solubility in surfactant solutions for latex systems. in Materials Research Society Symposium Proceedings. vol. 894, pp. 139-146, Combinatorial Methods and Informatics in Materials Science, Boston, MA, United States, 11/28/05.

Investigation of antimicrobial peptide salts : Efficacy and solubility in surfactant solutions for latex systems. / Wicks, Douglas A.; Rhoades, Alicyn Marie; Williamson, John S.; Miriyala, Bruhaspathy.

Materials Research Society Symposium Proceedings. Vol. 894 2006. p. 139-146.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

TY - GEN

T1 - Investigation of antimicrobial peptide salts

T2 - Efficacy and solubility in surfactant solutions for latex systems

AU - Wicks, Douglas A.

AU - Rhoades, Alicyn Marie

AU - Williamson, John S.

AU - Miriyala, Bruhaspathy

PY - 2006

Y1 - 2006

N2 - The study and application of antimicrobial peptides is a growing niche field in the areas of pharmaceutics and medicinal chemistry. As a result, the majority of testing and development is completed under in vitro conditions. The use of synthetically derived antimicrobial peptides in applications outside the medical realm is a relatively untapped field, with the significance of interactions between antimicrobial oligopeptides and the ingredients of polymer systems being largely unknown. Water-based polymer coatings systems are attractive targets for microbial invasion because of their inherent material properties. Water-based polymer latex coatings contain a number of components which aide in stabilization and coalescence of the polymer particles, such as surfactants and polymeric cellulose-derived molecules, with several types of molecular structures existing for each, Microbes are able to flourish within the water phase of the latexes while taking sustenance from these dispersion components, resulting in a loss of properties commonly known as 'spoilage'. This work addresses the impact of formulation variables, specifically surfactant structure, on the solution and antimicrobial behavior of a model antimicrobial oligopeptides through the use of HT absorbance measurements.

AB - The study and application of antimicrobial peptides is a growing niche field in the areas of pharmaceutics and medicinal chemistry. As a result, the majority of testing and development is completed under in vitro conditions. The use of synthetically derived antimicrobial peptides in applications outside the medical realm is a relatively untapped field, with the significance of interactions between antimicrobial oligopeptides and the ingredients of polymer systems being largely unknown. Water-based polymer coatings systems are attractive targets for microbial invasion because of their inherent material properties. Water-based polymer latex coatings contain a number of components which aide in stabilization and coalescence of the polymer particles, such as surfactants and polymeric cellulose-derived molecules, with several types of molecular structures existing for each, Microbes are able to flourish within the water phase of the latexes while taking sustenance from these dispersion components, resulting in a loss of properties commonly known as 'spoilage'. This work addresses the impact of formulation variables, specifically surfactant structure, on the solution and antimicrobial behavior of a model antimicrobial oligopeptides through the use of HT absorbance measurements.

UR - http://www.scopus.com/inward/record.url?scp=33745411737&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33745411737&partnerID=8YFLogxK

M3 - Conference contribution

SN - 1558998489

SN - 9781558998483

VL - 894

SP - 139

EP - 146

BT - Materials Research Society Symposium Proceedings

ER -

Wicks DA, Rhoades AM, Williamson JS, Miriyala B. Investigation of antimicrobial peptide salts: Efficacy and solubility in surfactant solutions for latex systems. In Materials Research Society Symposium Proceedings. Vol. 894. 2006. p. 139-146