Involuntary smoking and head and neck cancer risk: Pooled analysis in the International Head and Neck Cancer Epidemiology Consortium

Yuan Chin Amy Lee, Paolo Boffetta, Erich M. Sturgis, Qingyi Wei, Zuo Feng Zhang, Joshua Muscat, Philip Lazarus, Elena Matos, Richard B. Hayes, Deborah M. Winn, David Zaridze, Victor Wünsch-Filho, Jose Eluf-Neto, Sergio Koifman, Dana Mates, Maria Paula Curado, Ana Menezes, Leticia Fernandez, Alexander W. Daudt, Neonila Szeszenia-DabrowskaEleonora Fabianova, Peter Rudnai, Gilles Ferro, Julien Berthiller, Paul Brennan, Mia Hashibe

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Abstract

Although active tobacco smoking has been identified as a major risk factor for head and neck cancer, involuntary smoking has not been adequately evaluated because of the relatively low statistical power in previous studies. We took advantage of data pooled in the International Head and Neck Cancer Epidemiology Consortium to evaluate the role of involuntary smoking in head and neck carcinogenesis. Involuntary smoking exposure data were pooled across six case-control studies in Central Europe, Latin America, and the United States. Adjusted odds ratios (OR) and 95% confidence interval (95% CI) were estimated for 542 cases and 2,197 controls who reported never using tobacco, and the heterogeneity among the study-specific ORs was assessed. In addition, stratified analyses were done by subsite. No effect of ever involuntary smoking exposure either at home or at work was observed for head and neck cancer overall. However, long duration of involuntary smoking exposure at home and at work was associated with an increased risk (OR for >15 years at home, 1.60; 95%CI, 1.12-2.28; Ptrend < 0.01; OR for >15 years at work, 1.55; 95% CI, 1.04-2.30; Ptrend = 0.13). The effect of duration of involuntary smoking exposure at home was stronger for pharyngeal and laryngeal cancers than for other subsites. An association between involuntary smoking exposure and the risk of head and neck cancer, particularly pharyngeal and laryngeal cancers, was observed for long duration of exposure. These results are consistent with those for active smoking and suggest that elimination of involuntary smoking exposure might reduce head and neck cancer risk among never smokers.

Original languageEnglish (US)
Pages (from-to)1974-1981
Number of pages8
JournalCancer Epidemiology Biomarkers and Prevention
Volume17
Issue number8
DOIs
StatePublished - Aug 2008

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All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Oncology

Cite this

Lee, Y. C. A., Boffetta, P., Sturgis, E. M., Wei, Q., Zhang, Z. F., Muscat, J., Lazarus, P., Matos, E., Hayes, R. B., Winn, D. M., Zaridze, D., Wünsch-Filho, V., Eluf-Neto, J., Koifman, S., Mates, D., Curado, M. P., Menezes, A., Fernandez, L., Daudt, A. W., ... Hashibe, M. (2008). Involuntary smoking and head and neck cancer risk: Pooled analysis in the International Head and Neck Cancer Epidemiology Consortium. Cancer Epidemiology Biomarkers and Prevention, 17(8), 1974-1981. https://doi.org/10.1158/1055-9965.EPI-08-0047