Involvement of apoptosis in ovarian follicular atresia and postovulatory regression

Jonathan L. Tilly, Kim I. Kowalski, Alan Leslie Johnson, Aaron J.W. Hsueh

Research output: Contribution to journalArticle

515 Citations (Scopus)

Abstract

In the ovary, greater than 99% of the follicles present at birth are destined to degenerate during life. In humans, less than 400 of the more than 400, 000 follicles found at puberty will eventually ovulate whereas the overwhelming majority of follicles undergo atresia. Although follicular atresia plays a critical role during the recruitment of follicles for ovulation, the exact mechanism of this process is unknown. In chicken and porcine ovaries, atretic follicles can be morphologically distinguished from their healthy counterparts of the same size. Adapting a sensitive 3’-end labeling method for DNA analysis, we identified internucleosomal cleavage of cellular DNA in atretic (but not normal) follicles of both animal species, resembling that found during programmed cell death in embryogenesis, autoimmune T-cell removal and prostate regression. The present findings provide a basis for elucidating the hormonal signals involved in the initiation of follicular atresia during follicle recruitment, reproductive aging and premature ovarian failure.

Original languageEnglish (US)
Pages (from-to)2799-2801
Number of pages3
JournalEndocrinology
Volume129
Issue number5
DOIs
StatePublished - Jan 1 1991

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Follicular Atresia
Ovary
Apoptosis
Primary Ovarian Insufficiency
DNA Cleavage
Ovarian Follicle
Puberty
Ovulation
Embryonic Development
Prostate
Chickens
Cell Death
Swine
Parturition
T-Lymphocytes
DNA

All Science Journal Classification (ASJC) codes

  • Endocrinology

Cite this

Tilly, J. L., Kowalski, K. I., Johnson, A. L., & Hsueh, A. J. W. (1991). Involvement of apoptosis in ovarian follicular atresia and postovulatory regression. Endocrinology, 129(5), 2799-2801. https://doi.org/10.1210/endo-129-5-2799
Tilly, Jonathan L. ; Kowalski, Kim I. ; Johnson, Alan Leslie ; Hsueh, Aaron J.W. / Involvement of apoptosis in ovarian follicular atresia and postovulatory regression. In: Endocrinology. 1991 ; Vol. 129, No. 5. pp. 2799-2801.
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Tilly, JL, Kowalski, KI, Johnson, AL & Hsueh, AJW 1991, 'Involvement of apoptosis in ovarian follicular atresia and postovulatory regression', Endocrinology, vol. 129, no. 5, pp. 2799-2801. https://doi.org/10.1210/endo-129-5-2799

Involvement of apoptosis in ovarian follicular atresia and postovulatory regression. / Tilly, Jonathan L.; Kowalski, Kim I.; Johnson, Alan Leslie; Hsueh, Aaron J.W.

In: Endocrinology, Vol. 129, No. 5, 01.01.1991, p. 2799-2801.

Research output: Contribution to journalArticle

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