Involvement of polyamines in the progestin-induced stimulation of endometrial glycogen synthesis during organ culture

P. D. Feil, Anthony Pegg, Laurence Demers, C. W. Bardin

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

Addition of progesterone to an organ culture of endometrial fragments increased glycogen levels 2-3 fold. Concomitant with this increase in glycogen was an increase in S-adenosyl-L-methionine decarboxylase activity and the conversion of putrescine into spermidine. When an inhibitor of S-adenosyl-L-methionine decarboxylase, methylglyoxyl bis(guanylhydrazone), was added to the culture with progesterone, glycogen synthesis was blocked. Inhibition of glycogen synthesis was reversed by the addition of spermidine, suggesting that spermidine synthesis may be necessary for the progestin-induced accumulation of endometrial glycogen.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume75
Issue number1
DOIs
StatePublished - Mar 7 1977

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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