Involvement of the polyamine pathway in breast cancer progression

Andrea Manni, Rhea Grove, Susan Kunselman, Marcelo Aldaz

Research output: Contribution to journalArticle

56 Scopus citations

Abstract

These experiments were designed to test the role of the polyamine pathway in breast cancer progression utilizing an experimental system based on the development of ovary-independent rat mammary tumors and their sequential transplantation into syngeneic hosts. Three key enzymes involved in the PA biosynthetic/catabolic pathway (ornithine-decarboxylase (ODC), S-adenosylmethionine decarboxylase (SAMDC), and spermidine/spermine N′-acetyltransferase (SSAT)) were measured in tumors at different stages of progression. The most significant finding was the association between increased ODC activity and the acquisition of a hormone-independent, poorly differentiated phenotype. SSAT levels tended to be higher in hormone-independent tumors and, in this tumor category, they tended to be positively correlated with differentiation. However, significant interaction between hormone dependence and differentiation status on SSAT expression prevented reliable assessment of the possibly complex role of this enzyme in tumor progression. Neither hormone dependence nor differentiation status were correlated with SAMDC levels. We conclude that, among the three enzymes tested, ODC overexpression is the most significant alteration in the PA metabolic pathway associated with breast cancer progression in this experimental system.

Original languageEnglish (US)
Pages (from-to)49-57
Number of pages9
JournalCancer Letters
Volume92
Issue number1
DOIs
StatePublished - May 25 1995

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

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