Inward diastolic motion

A normal component of isovolumic relaxation and rapid refill

J. J. McInerney, Robert Aronoff, S. H. Blasko, G. L. Copenhaver, M. D. Herr

Research output: Contribution to journalArticle

Abstract

Many reports note expansive events occurring in the left ventricle during isovolumic relaxation. Expansions during isovolumic relaxation require compensatory inward displacements elsewhere in the ventricle. The location and character of such compensatory displacements have been a continuing source of speculation. Using a high-precision Compton backscatter imaging (CBI) technique, we have detected an early diastolic inward motion that initiates during isovolumic relaxation on the right and left epicardial free walls of the heart in 100% of the 14 normal canines we have studied. This inward motion is first detected 20-30 ms after left ventricular maximal rate of pressure decrease over time (-dP/dt(max)), lasts into the early rapid filling phase with a mean duration of 92 ± 5 (SE) ms, and ends ~30 ms after opening of the mitral valve. Maximum wall velocities during this time period (~20 mm/s) exceed those occurring in the same regions during systole. Inward surface displacements in the areas undergoing inward motion average 1.1 ± 0.2 and 0.9 ± 0.2 mm on the left and right side of the heart, respectively.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume266
Issue number6 35-6
StatePublished - 1994

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Systole
Mitral Valve
Heart Ventricles
Canidae
Pressure

All Science Journal Classification (ASJC) codes

  • Physiology

Cite this

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title = "Inward diastolic motion: A normal component of isovolumic relaxation and rapid refill",
abstract = "Many reports note expansive events occurring in the left ventricle during isovolumic relaxation. Expansions during isovolumic relaxation require compensatory inward displacements elsewhere in the ventricle. The location and character of such compensatory displacements have been a continuing source of speculation. Using a high-precision Compton backscatter imaging (CBI) technique, we have detected an early diastolic inward motion that initiates during isovolumic relaxation on the right and left epicardial free walls of the heart in 100{\%} of the 14 normal canines we have studied. This inward motion is first detected 20-30 ms after left ventricular maximal rate of pressure decrease over time (-dP/dt(max)), lasts into the early rapid filling phase with a mean duration of 92 ± 5 (SE) ms, and ends ~30 ms after opening of the mitral valve. Maximum wall velocities during this time period (~20 mm/s) exceed those occurring in the same regions during systole. Inward surface displacements in the areas undergoing inward motion average 1.1 ± 0.2 and 0.9 ± 0.2 mm on the left and right side of the heart, respectively.",
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Inward diastolic motion : A normal component of isovolumic relaxation and rapid refill. / McInerney, J. J.; Aronoff, Robert; Blasko, S. H.; Copenhaver, G. L.; Herr, M. D.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 266, No. 6 35-6, 1994.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Inward diastolic motion

T2 - A normal component of isovolumic relaxation and rapid refill

AU - McInerney, J. J.

AU - Aronoff, Robert

AU - Blasko, S. H.

AU - Copenhaver, G. L.

AU - Herr, M. D.

PY - 1994

Y1 - 1994

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AB - Many reports note expansive events occurring in the left ventricle during isovolumic relaxation. Expansions during isovolumic relaxation require compensatory inward displacements elsewhere in the ventricle. The location and character of such compensatory displacements have been a continuing source of speculation. Using a high-precision Compton backscatter imaging (CBI) technique, we have detected an early diastolic inward motion that initiates during isovolumic relaxation on the right and left epicardial free walls of the heart in 100% of the 14 normal canines we have studied. This inward motion is first detected 20-30 ms after left ventricular maximal rate of pressure decrease over time (-dP/dt(max)), lasts into the early rapid filling phase with a mean duration of 92 ± 5 (SE) ms, and ends ~30 ms after opening of the mitral valve. Maximum wall velocities during this time period (~20 mm/s) exceed those occurring in the same regions during systole. Inward surface displacements in the areas undergoing inward motion average 1.1 ± 0.2 and 0.9 ± 0.2 mm on the left and right side of the heart, respectively.

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