TY - JOUR
T1 - IPRO+/−
T2 - Computational Protein Design Tool Allowing for Insertions and Deletions
AU - Chowdhury, Ratul
AU - Grisewood, Matthew J.
AU - Boorla, Veda Sheersh
AU - Yan, Qiang
AU - Pfleger, Brian F.
AU - Maranas, Costas D.
N1 - Funding Information:
This work was supported by the National Science Foundation grant CBET-1703274 and the Department of Energy (DOE) - Center for Bioenergy Innovation grant DE-AC05-000R22725. M.J.G. and C.D.M. conceived the study. M.J.G. wrote initial modules for the software. R.C. wrote the rest of the software, automated it, and performed the test cases and wrote the manuscript. V.S.B. wrote the Indel-Maker module and helped edit the manuscript. Q.Y. performed the experiments on ?TesA and wrote the experimental methods. C.D.M. and B.F.P. provided useful insights and helped edit the manuscript. The authors declare no competing interests.
Funding Information:
The United States National Science Foundation grant CBET-1703274 supports this collaboration. We also acknowledge the Center for Bioenergy Innovation of the United States Department of Energy grant DE-SC0018420 for funding our plant enzyme redesign work.
Publisher Copyright:
© 2020
PY - 2020/12/1
Y1 - 2020/12/1
N2 - Chowdhury et al. describe an optimization-based protein design tool to identify combinations of protein residue positions, which can allow extra amino acids to be inserted, altered, or even removed from the sequence to arrive at a sequence whose corresponding structure achieves a desired binding affinity with a target molecule.
AB - Chowdhury et al. describe an optimization-based protein design tool to identify combinations of protein residue positions, which can allow extra amino acids to be inserted, altered, or even removed from the sequence to arrive at a sequence whose corresponding structure achieves a desired binding affinity with a target molecule.
UR - http://www.scopus.com/inward/record.url?scp=85090484443&partnerID=8YFLogxK
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U2 - 10.1016/j.str.2020.08.003
DO - 10.1016/j.str.2020.08.003
M3 - Article
C2 - 32857964
AN - SCOPUS:85090484443
VL - 28
SP - 1344-1357.e4
JO - Structure with Folding & design
JF - Structure with Folding & design
SN - 0969-2126
IS - 12
ER -