IPRO+/−: Computational Protein Design Tool Allowing for Insertions and Deletions

Ratul Chowdhury, Matthew J. Grisewood, Veda Sheersh Boorla, Qiang Yan, Brian F. Pfleger, Costas D. Maranas

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Chowdhury et al. describe an optimization-based protein design tool to identify combinations of protein residue positions, which can allow extra amino acids to be inserted, altered, or even removed from the sequence to arrive at a sequence whose corresponding structure achieves a desired binding affinity with a target molecule.

Original languageEnglish (US)
Pages (from-to)1344-1357.e4
JournalStructure
Volume28
Issue number12
DOIs
StatePublished - Dec 1 2020

All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Molecular Biology

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