TY - JOUR
T1 - IPRO+/−
T2 - Computational Protein Design Tool Allowing for Insertions and Deletions
AU - Chowdhury, Ratul
AU - Grisewood, Matthew J.
AU - Boorla, Veda Sheersh
AU - Yan, Qiang
AU - Pfleger, Brian F.
AU - Maranas, Costas D.
N1 - Funding Information:
The United States National Science Foundation grant CBET-1703274 supports this collaboration. We also acknowledge the Center for Bioenergy Innovation of the United States Department of Energy grant DE-SC0018420 for funding our plant enzyme redesign work.
PY - 2020/12/1
Y1 - 2020/12/1
N2 - Chowdhury et al. describe an optimization-based protein design tool to identify combinations of protein residue positions, which can allow extra amino acids to be inserted, altered, or even removed from the sequence to arrive at a sequence whose corresponding structure achieves a desired binding affinity with a target molecule.
AB - Chowdhury et al. describe an optimization-based protein design tool to identify combinations of protein residue positions, which can allow extra amino acids to be inserted, altered, or even removed from the sequence to arrive at a sequence whose corresponding structure achieves a desired binding affinity with a target molecule.
UR - http://www.scopus.com/inward/record.url?scp=85090484443&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85090484443&partnerID=8YFLogxK
U2 - 10.1016/j.str.2020.08.003
DO - 10.1016/j.str.2020.08.003
M3 - Article
C2 - 32857964
AN - SCOPUS:85090484443
VL - 28
SP - 1344-1357.e4
JO - Structure with Folding & design
JF - Structure with Folding & design
SN - 0969-2126
IS - 12
ER -