IQ and variation in the number of fragile X CGG repeats: No association in a normal sample

J. K. Daniels, Michael J. Owen, Peter McGuffin, Lee Thompson, Douglas K. Detterman, Michael J. Chorney, Karen Chorney, Deborah Smith, Patricia Skuder, Sylvia Vignetti, Gerald E. McClearn, Robert Plomin

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Abstract

Fragile X mental retardation is associated with an unstable expansion of a CGG repeat in the FMR-1 gene on the X chromosome (Xq27.3). We asked whether variation in the number of FMR-1 CGG repeats relates to IQ in the general population. FMR-1 CGG repeats were genotyped for three groups: low IQ (mean IQ = 71, N = 35), middle IQ (mean IQ = 103, N = 19), and high IQ (mean IQ = 137, N = 49). The IQ groups did not differ significantly in number of FMR-1 CGG repeats for males or females.

Original languageEnglish (US)
Pages (from-to)45-50
Number of pages6
JournalIntelligence
Volume19
Issue number1
DOIs
StatePublished - Jan 1 1994

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X-Linked Genes
Intellectual Disability
Population
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All Science Journal Classification (ASJC) codes

  • Experimental and Cognitive Psychology
  • Developmental and Educational Psychology
  • Arts and Humanities (miscellaneous)

Cite this

Daniels, J. K., Owen, M. J., McGuffin, P., Thompson, L., Detterman, D. K., Chorney, M. J., ... Plomin, R. (1994). IQ and variation in the number of fragile X CGG repeats: No association in a normal sample. Intelligence, 19(1), 45-50. https://doi.org/10.1016/0160-2896(94)90052-3
Daniels, J. K. ; Owen, Michael J. ; McGuffin, Peter ; Thompson, Lee ; Detterman, Douglas K. ; Chorney, Michael J. ; Chorney, Karen ; Smith, Deborah ; Skuder, Patricia ; Vignetti, Sylvia ; McClearn, Gerald E. ; Plomin, Robert. / IQ and variation in the number of fragile X CGG repeats : No association in a normal sample. In: Intelligence. 1994 ; Vol. 19, No. 1. pp. 45-50.
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Daniels, JK, Owen, MJ, McGuffin, P, Thompson, L, Detterman, DK, Chorney, MJ, Chorney, K, Smith, D, Skuder, P, Vignetti, S, McClearn, GE & Plomin, R 1994, 'IQ and variation in the number of fragile X CGG repeats: No association in a normal sample', Intelligence, vol. 19, no. 1, pp. 45-50. https://doi.org/10.1016/0160-2896(94)90052-3

IQ and variation in the number of fragile X CGG repeats : No association in a normal sample. / Daniels, J. K.; Owen, Michael J.; McGuffin, Peter; Thompson, Lee; Detterman, Douglas K.; Chorney, Michael J.; Chorney, Karen; Smith, Deborah; Skuder, Patricia; Vignetti, Sylvia; McClearn, Gerald E.; Plomin, Robert.

In: Intelligence, Vol. 19, No. 1, 01.01.1994, p. 45-50.

Research output: Contribution to journalArticle

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Daniels JK, Owen MJ, McGuffin P, Thompson L, Detterman DK, Chorney MJ et al. IQ and variation in the number of fragile X CGG repeats: No association in a normal sample. Intelligence. 1994 Jan 1;19(1):45-50. https://doi.org/10.1016/0160-2896(94)90052-3