IQ and variation in the number of fragile X CGG repeats: No association in a normal sample

J. K. Daniels, Michael J. Owen, Peter McGuffin, Lee Thompson, Douglas K. Detterman, Michael Chorney, Karen Chorney, Deborah Smith, Patricia Skuder, Sylvia Vignetti, Gerald E. McClearn, Robert Plomin

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Fragile X mental retardation is associated with an unstable expansion of a CGG repeat in the FMR-1 gene on the X chromosome (Xq27.3). We asked whether variation in the number of FMR-1 CGG repeats relates to IQ in the general population. FMR-1 CGG repeats were genotyped for three groups: low IQ (mean IQ = 71, N = 35), middle IQ (mean IQ = 103, N = 19), and high IQ (mean IQ = 137, N = 49). The IQ groups did not differ significantly in number of FMR-1 CGG repeats for males or females.

Original languageEnglish (US)
Pages (from-to)45-50
Number of pages6
JournalIntelligence
Volume19
Issue number1
DOIs
StatePublished - Jan 1 1994

All Science Journal Classification (ASJC) codes

  • Experimental and Cognitive Psychology
  • Developmental and Educational Psychology
  • Arts and Humanities (miscellaneous)

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