Abstract

Neurodegenerative disease is a condition in which subpopulations of neuronal cells of the brain and spinal cord are selectively lost. A common event in many neurodegenerative diseases is the increased level of endoplasmic reticulum (ER) stress caused by accumulation and deposits of inclusion bodies that contain abnormal aggregated proteins. However, the basis of how ER stress contributes to the selective neuronal vulnerability and degeneration remain elusive. Iron accumulation in the central nerve system is consistently present in many neurodegenerative diseases. In the past 5 years we have begun to show a relationship between polymorphisms in the HFE (high iron) gene and the risk of neurodegenerative disorders. Recent findings have suggested a connection between ER stress and iron metabolism and neurodegeneration. Here we review how the different levels of chronic ER stress contribute to the different fates of neurons, namely the adaptive response and neuronal death. And, we discuss the roles of iron and HFE genotype in selective neuronal vulnerability and degeneration through modifying the ER stress level.

Original languageEnglish (US)
Pages (from-to)837-845
Number of pages9
JournalBioMetals
Volume25
Issue number4
DOIs
StatePublished - Aug 1 2012

Fingerprint

Neurodegenerative diseases
Endoplasmic Reticulum Stress
neurodegenerative diseases
Neurodegenerative Diseases
endoplasmic reticulum
Iron
iron
neurons
Inclusion Bodies
inclusion bodies
Polymorphism
Metabolism
spinal cord
Neurons
Brain
Spinal Cord
nerve tissue
Deposits
Genes
Genotype

All Science Journal Classification (ASJC) codes

  • Biomaterials
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • Metals and Alloys

Cite this

Liu, Yiting ; Connor, James. / Iron and ER stress in neurodegenerative disease. In: BioMetals. 2012 ; Vol. 25, No. 4. pp. 837-845.
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Iron and ER stress in neurodegenerative disease. / Liu, Yiting; Connor, James.

In: BioMetals, Vol. 25, No. 4, 01.08.2012, p. 837-845.

Research output: Contribution to journalArticle

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