Iron deficiency: Differential effects on monoamine transporters

Maggie S. Burhans, Catherine Dailey, Zachary Beard, Jason Wiesinger, Laura E. Murray-Kolb, Byron C. Jones, John L. Beard

Research output: Contribution to journalArticle

86 Citations (Scopus)

Abstract

In this study, we extend previous work on iron deficiency and dopamine (DA) transporters to include an examination of central serotonin (5-HT) and noradrenergic (NE) transporters. Rats were fed either iron deficient (ID) or iron adequate (CN) diets from weaning until adulthood. In males, an additional group of iron deficient animals (IR) were given iron supplementation. DA, 5-HT, and NE transporter binding was done in situ on thin sections. ID males, but not females, decreased DA transporter binding in the nucleus accumbens, caudate putamen and substantia nigra by 20-40%. ID males also had a 20-30% reduction in 5-HT transporter binding in several areas (nucleus accumbens, olfactory tubercle, colliculus) while in ID females there was 15-25% increased serotonin transporter binding in the olfactory tubercle, zona incerta, anteroventral thalamic nucleus and vestibular nucleus. Iron deficiency reduced 3H-nisoxetine binding to the NE transporter in locus ceruleus and anteroventral thalamic nucleus in males but not females. Only some of the changes observed in DA, serotonin and NE transporter binding were reversible by iron supplementation. These findings show that iron deficiency affects monoamine systems related to homeostasis and in most cases males appear to be more vulnerable than females.

Original languageEnglish (US)
Pages (from-to)31-38
Number of pages8
JournalNutritional Neuroscience
Volume8
Issue number1
DOIs
StatePublished - Feb 1 2005

Fingerprint

Iron
Serotonin
Anterior Thalamic Nuclei
Serotonin Plasma Membrane Transport Proteins
Dopamine Plasma Membrane Transport Proteins
nisoxetine
Nucleus Accumbens
Dopamine
Vestibular Nuclei
Locus Coeruleus
Putamen
Substantia Nigra
Weaning
Homeostasis
Diet

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Neuroscience(all)
  • Nutrition and Dietetics

Cite this

Burhans, M. S., Dailey, C., Beard, Z., Wiesinger, J., Murray-Kolb, L. E., Jones, B. C., & Beard, J. L. (2005). Iron deficiency: Differential effects on monoamine transporters. Nutritional Neuroscience, 8(1), 31-38. https://doi.org/10.1080/10284150500047070
Burhans, Maggie S. ; Dailey, Catherine ; Beard, Zachary ; Wiesinger, Jason ; Murray-Kolb, Laura E. ; Jones, Byron C. ; Beard, John L. / Iron deficiency : Differential effects on monoamine transporters. In: Nutritional Neuroscience. 2005 ; Vol. 8, No. 1. pp. 31-38.
@article{556d12eaeecf473696fe84a60e4abf92,
title = "Iron deficiency: Differential effects on monoamine transporters",
abstract = "In this study, we extend previous work on iron deficiency and dopamine (DA) transporters to include an examination of central serotonin (5-HT) and noradrenergic (NE) transporters. Rats were fed either iron deficient (ID) or iron adequate (CN) diets from weaning until adulthood. In males, an additional group of iron deficient animals (IR) were given iron supplementation. DA, 5-HT, and NE transporter binding was done in situ on thin sections. ID males, but not females, decreased DA transporter binding in the nucleus accumbens, caudate putamen and substantia nigra by 20-40{\%}. ID males also had a 20-30{\%} reduction in 5-HT transporter binding in several areas (nucleus accumbens, olfactory tubercle, colliculus) while in ID females there was 15-25{\%} increased serotonin transporter binding in the olfactory tubercle, zona incerta, anteroventral thalamic nucleus and vestibular nucleus. Iron deficiency reduced 3H-nisoxetine binding to the NE transporter in locus ceruleus and anteroventral thalamic nucleus in males but not females. Only some of the changes observed in DA, serotonin and NE transporter binding were reversible by iron supplementation. These findings show that iron deficiency affects monoamine systems related to homeostasis and in most cases males appear to be more vulnerable than females.",
author = "Burhans, {Maggie S.} and Catherine Dailey and Zachary Beard and Jason Wiesinger and Murray-Kolb, {Laura E.} and Jones, {Byron C.} and Beard, {John L.}",
year = "2005",
month = "2",
day = "1",
doi = "10.1080/10284150500047070",
language = "English (US)",
volume = "8",
pages = "31--38",
journal = "Nutritional Neuroscience",
issn = "1028-415X",
publisher = "Maney Publishing",
number = "1",

}

Burhans, MS, Dailey, C, Beard, Z, Wiesinger, J, Murray-Kolb, LE, Jones, BC & Beard, JL 2005, 'Iron deficiency: Differential effects on monoamine transporters', Nutritional Neuroscience, vol. 8, no. 1, pp. 31-38. https://doi.org/10.1080/10284150500047070

Iron deficiency : Differential effects on monoamine transporters. / Burhans, Maggie S.; Dailey, Catherine; Beard, Zachary; Wiesinger, Jason; Murray-Kolb, Laura E.; Jones, Byron C.; Beard, John L.

In: Nutritional Neuroscience, Vol. 8, No. 1, 01.02.2005, p. 31-38.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Iron deficiency

T2 - Differential effects on monoamine transporters

AU - Burhans, Maggie S.

AU - Dailey, Catherine

AU - Beard, Zachary

AU - Wiesinger, Jason

AU - Murray-Kolb, Laura E.

AU - Jones, Byron C.

AU - Beard, John L.

PY - 2005/2/1

Y1 - 2005/2/1

N2 - In this study, we extend previous work on iron deficiency and dopamine (DA) transporters to include an examination of central serotonin (5-HT) and noradrenergic (NE) transporters. Rats were fed either iron deficient (ID) or iron adequate (CN) diets from weaning until adulthood. In males, an additional group of iron deficient animals (IR) were given iron supplementation. DA, 5-HT, and NE transporter binding was done in situ on thin sections. ID males, but not females, decreased DA transporter binding in the nucleus accumbens, caudate putamen and substantia nigra by 20-40%. ID males also had a 20-30% reduction in 5-HT transporter binding in several areas (nucleus accumbens, olfactory tubercle, colliculus) while in ID females there was 15-25% increased serotonin transporter binding in the olfactory tubercle, zona incerta, anteroventral thalamic nucleus and vestibular nucleus. Iron deficiency reduced 3H-nisoxetine binding to the NE transporter in locus ceruleus and anteroventral thalamic nucleus in males but not females. Only some of the changes observed in DA, serotonin and NE transporter binding were reversible by iron supplementation. These findings show that iron deficiency affects monoamine systems related to homeostasis and in most cases males appear to be more vulnerable than females.

AB - In this study, we extend previous work on iron deficiency and dopamine (DA) transporters to include an examination of central serotonin (5-HT) and noradrenergic (NE) transporters. Rats were fed either iron deficient (ID) or iron adequate (CN) diets from weaning until adulthood. In males, an additional group of iron deficient animals (IR) were given iron supplementation. DA, 5-HT, and NE transporter binding was done in situ on thin sections. ID males, but not females, decreased DA transporter binding in the nucleus accumbens, caudate putamen and substantia nigra by 20-40%. ID males also had a 20-30% reduction in 5-HT transporter binding in several areas (nucleus accumbens, olfactory tubercle, colliculus) while in ID females there was 15-25% increased serotonin transporter binding in the olfactory tubercle, zona incerta, anteroventral thalamic nucleus and vestibular nucleus. Iron deficiency reduced 3H-nisoxetine binding to the NE transporter in locus ceruleus and anteroventral thalamic nucleus in males but not females. Only some of the changes observed in DA, serotonin and NE transporter binding were reversible by iron supplementation. These findings show that iron deficiency affects monoamine systems related to homeostasis and in most cases males appear to be more vulnerable than females.

UR - http://www.scopus.com/inward/record.url?scp=18344390691&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=18344390691&partnerID=8YFLogxK

U2 - 10.1080/10284150500047070

DO - 10.1080/10284150500047070

M3 - Article

C2 - 15909765

AN - SCOPUS:18344390691

VL - 8

SP - 31

EP - 38

JO - Nutritional Neuroscience

JF - Nutritional Neuroscience

SN - 1028-415X

IS - 1

ER -