Iron metabolism in infants and children

Bo Lönnerdal, Shannon L. Kelleher

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Meeting the iron requirements of infants and children is difficult, and supplementation orfortification of food with iron is often recommended. Although iron supplementation of infants and children with iron deficiency and iron-deficiency anemia may be beneficial, recen studies suggest that this may not be the case for those with adequate iron status, and adverse effects have been noted. The recent discoveries of proteins and peptide regulating iron absorption have enhanced our knowledge of iron metabolism in infants and children. Iron is taken up in the small intestine by divalent metal transporter-1 and is either stored by ferritin inside the mucosal cell or transported to the systemic circulation by ferroportin, while being oxidized by hephaestin to be incorporated into transferrin. Hepcidin, a small peptide synthesized by the liver, can sense iron stores and regulates iron transport by inhibition of ferroportin. However, regulation of iron transporters is immature in infants, possibly explaining the adverse effects of iron supplementation. Interactions among iron, vitamin A, zinc, and copper need to be considered when evaluating the effects of iron supplementation on infants and children.

Original languageEnglish (US)
JournalFood and Nutrition Bulletin
Volume28
Issue number4 SUPPL.
StatePublished - Dec 2007

Fingerprint

infant
Iron
metabolism
iron
food
transporters
regulation
peptide
adverse effects
peptides
interaction
Hepcidins
iron deficiency anemia
iron absorption
Peptides
Iron-Deficiency Anemias
ferritin
transferrin
anemia
Transferrin

All Science Journal Classification (ASJC) codes

  • Geography, Planning and Development
  • Nutrition and Dietetics

Cite this

Lönnerdal, B., & Kelleher, S. L. (2007). Iron metabolism in infants and children. Food and Nutrition Bulletin, 28(4 SUPPL.).
Lönnerdal, Bo ; Kelleher, Shannon L. / Iron metabolism in infants and children. In: Food and Nutrition Bulletin. 2007 ; Vol. 28, No. 4 SUPPL.
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Lönnerdal, B & Kelleher, SL 2007, 'Iron metabolism in infants and children', Food and Nutrition Bulletin, vol. 28, no. 4 SUPPL..

Iron metabolism in infants and children. / Lönnerdal, Bo; Kelleher, Shannon L.

In: Food and Nutrition Bulletin, Vol. 28, No. 4 SUPPL., 12.2007.

Research output: Contribution to journalArticle

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AU - Lönnerdal, Bo

AU - Kelleher, Shannon L.

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N2 - Meeting the iron requirements of infants and children is difficult, and supplementation orfortification of food with iron is often recommended. Although iron supplementation of infants and children with iron deficiency and iron-deficiency anemia may be beneficial, recen studies suggest that this may not be the case for those with adequate iron status, and adverse effects have been noted. The recent discoveries of proteins and peptide regulating iron absorption have enhanced our knowledge of iron metabolism in infants and children. Iron is taken up in the small intestine by divalent metal transporter-1 and is either stored by ferritin inside the mucosal cell or transported to the systemic circulation by ferroportin, while being oxidized by hephaestin to be incorporated into transferrin. Hepcidin, a small peptide synthesized by the liver, can sense iron stores and regulates iron transport by inhibition of ferroportin. However, regulation of iron transporters is immature in infants, possibly explaining the adverse effects of iron supplementation. Interactions among iron, vitamin A, zinc, and copper need to be considered when evaluating the effects of iron supplementation on infants and children.

AB - Meeting the iron requirements of infants and children is difficult, and supplementation orfortification of food with iron is often recommended. Although iron supplementation of infants and children with iron deficiency and iron-deficiency anemia may be beneficial, recen studies suggest that this may not be the case for those with adequate iron status, and adverse effects have been noted. The recent discoveries of proteins and peptide regulating iron absorption have enhanced our knowledge of iron metabolism in infants and children. Iron is taken up in the small intestine by divalent metal transporter-1 and is either stored by ferritin inside the mucosal cell or transported to the systemic circulation by ferroportin, while being oxidized by hephaestin to be incorporated into transferrin. Hepcidin, a small peptide synthesized by the liver, can sense iron stores and regulates iron transport by inhibition of ferroportin. However, regulation of iron transporters is immature in infants, possibly explaining the adverse effects of iron supplementation. Interactions among iron, vitamin A, zinc, and copper need to be considered when evaluating the effects of iron supplementation on infants and children.

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Lönnerdal B, Kelleher SL. Iron metabolism in infants and children. Food and Nutrition Bulletin. 2007 Dec;28(4 SUPPL.).