Iron, Myelin, and the Brain: Neuroimaging Meets Neurobiology

Harald E. Möller, Lucia Bossoni, James Connor, Robert R. Crichton, Mark D. Does, Roberta J. Ward, Luigi Zecca, Fabio A. Zucca, Itamar Ronen

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Although iron is crucial for neuronal functioning, many aspects of cerebral iron biology await clarification. The ability to quantify specific iron forms in the living brain would open new avenues for diagnosis, therapeutic monitoring, and understanding pathogenesis of diseases. A modality that allows assessment of brain tissue composition in vivo, in particular of iron deposits or myelin content on a submillimeter spatial scale, is magnetic resonance imaging (MRI). Multimodal strategies combining MRI with complementary analytical techniques ex vivo have emerged, which may lead to improved specificity. Interdisciplinary collaborations will be key to advance beyond simple correlative analyses in the biological interpretation of MRI data and to gain deeper insights into key factors leading to iron accumulation and/or redistribution associated with neurodegeneration.

Original languageEnglish (US)
Pages (from-to)384-401
Number of pages18
JournalTrends in Neurosciences
Volume42
Issue number6
DOIs
StatePublished - Jun 1 2019

Fingerprint

Neurobiology
Myelin Sheath
Neuroimaging
Iron
Brain
Magnetic Resonance Imaging

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Möller, H. E., Bossoni, L., Connor, J., Crichton, R. R., Does, M. D., Ward, R. J., ... Ronen, I. (2019). Iron, Myelin, and the Brain: Neuroimaging Meets Neurobiology. Trends in Neurosciences, 42(6), 384-401. https://doi.org/10.1016/j.tins.2019.03.009
Möller, Harald E. ; Bossoni, Lucia ; Connor, James ; Crichton, Robert R. ; Does, Mark D. ; Ward, Roberta J. ; Zecca, Luigi ; Zucca, Fabio A. ; Ronen, Itamar. / Iron, Myelin, and the Brain : Neuroimaging Meets Neurobiology. In: Trends in Neurosciences. 2019 ; Vol. 42, No. 6. pp. 384-401.
@article{8fadf6f6073e481f89864b4a0a2a8318,
title = "Iron, Myelin, and the Brain: Neuroimaging Meets Neurobiology",
abstract = "Although iron is crucial for neuronal functioning, many aspects of cerebral iron biology await clarification. The ability to quantify specific iron forms in the living brain would open new avenues for diagnosis, therapeutic monitoring, and understanding pathogenesis of diseases. A modality that allows assessment of brain tissue composition in vivo, in particular of iron deposits or myelin content on a submillimeter spatial scale, is magnetic resonance imaging (MRI). Multimodal strategies combining MRI with complementary analytical techniques ex vivo have emerged, which may lead to improved specificity. Interdisciplinary collaborations will be key to advance beyond simple correlative analyses in the biological interpretation of MRI data and to gain deeper insights into key factors leading to iron accumulation and/or redistribution associated with neurodegeneration.",
author = "M{\"o}ller, {Harald E.} and Lucia Bossoni and James Connor and Crichton, {Robert R.} and Does, {Mark D.} and Ward, {Roberta J.} and Luigi Zecca and Zucca, {Fabio A.} and Itamar Ronen",
year = "2019",
month = "6",
day = "1",
doi = "10.1016/j.tins.2019.03.009",
language = "English (US)",
volume = "42",
pages = "384--401",
journal = "Trends in Neurosciences",
issn = "0378-5912",
publisher = "Elsevier Limited",
number = "6",

}

Möller, HE, Bossoni, L, Connor, J, Crichton, RR, Does, MD, Ward, RJ, Zecca, L, Zucca, FA & Ronen, I 2019, 'Iron, Myelin, and the Brain: Neuroimaging Meets Neurobiology', Trends in Neurosciences, vol. 42, no. 6, pp. 384-401. https://doi.org/10.1016/j.tins.2019.03.009

Iron, Myelin, and the Brain : Neuroimaging Meets Neurobiology. / Möller, Harald E.; Bossoni, Lucia; Connor, James; Crichton, Robert R.; Does, Mark D.; Ward, Roberta J.; Zecca, Luigi; Zucca, Fabio A.; Ronen, Itamar.

In: Trends in Neurosciences, Vol. 42, No. 6, 01.06.2019, p. 384-401.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Iron, Myelin, and the Brain

T2 - Neuroimaging Meets Neurobiology

AU - Möller, Harald E.

AU - Bossoni, Lucia

AU - Connor, James

AU - Crichton, Robert R.

AU - Does, Mark D.

AU - Ward, Roberta J.

AU - Zecca, Luigi

AU - Zucca, Fabio A.

AU - Ronen, Itamar

PY - 2019/6/1

Y1 - 2019/6/1

N2 - Although iron is crucial for neuronal functioning, many aspects of cerebral iron biology await clarification. The ability to quantify specific iron forms in the living brain would open new avenues for diagnosis, therapeutic monitoring, and understanding pathogenesis of diseases. A modality that allows assessment of brain tissue composition in vivo, in particular of iron deposits or myelin content on a submillimeter spatial scale, is magnetic resonance imaging (MRI). Multimodal strategies combining MRI with complementary analytical techniques ex vivo have emerged, which may lead to improved specificity. Interdisciplinary collaborations will be key to advance beyond simple correlative analyses in the biological interpretation of MRI data and to gain deeper insights into key factors leading to iron accumulation and/or redistribution associated with neurodegeneration.

AB - Although iron is crucial for neuronal functioning, many aspects of cerebral iron biology await clarification. The ability to quantify specific iron forms in the living brain would open new avenues for diagnosis, therapeutic monitoring, and understanding pathogenesis of diseases. A modality that allows assessment of brain tissue composition in vivo, in particular of iron deposits or myelin content on a submillimeter spatial scale, is magnetic resonance imaging (MRI). Multimodal strategies combining MRI with complementary analytical techniques ex vivo have emerged, which may lead to improved specificity. Interdisciplinary collaborations will be key to advance beyond simple correlative analyses in the biological interpretation of MRI data and to gain deeper insights into key factors leading to iron accumulation and/or redistribution associated with neurodegeneration.

UR - http://www.scopus.com/inward/record.url?scp=85064820499&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85064820499&partnerID=8YFLogxK

U2 - 10.1016/j.tins.2019.03.009

DO - 10.1016/j.tins.2019.03.009

M3 - Review article

C2 - 31047721

AN - SCOPUS:85064820499

VL - 42

SP - 384

EP - 401

JO - Trends in Neurosciences

JF - Trends in Neurosciences

SN - 0378-5912

IS - 6

ER -

Möller HE, Bossoni L, Connor J, Crichton RR, Does MD, Ward RJ et al. Iron, Myelin, and the Brain: Neuroimaging Meets Neurobiology. Trends in Neurosciences. 2019 Jun 1;42(6):384-401. https://doi.org/10.1016/j.tins.2019.03.009