Iron supplementation improves iron status and reduces morbidity in children with or without upper respiratory tract infections: A randomized controlled study in Colombo, Sri Lanka

Angela De Silva, Sunethra Atukorala, Irangani Weerasinghe, Namanjeet Ahluwalia

Research output: Contribution to journalArticle

68 Citations (Scopus)

Abstract

Background: Iron deficiency anemia and recurrent infections are common among children of low socioeconomic status. Objective: The objective was to evaluate the effects of iron supplementation on iron status and morbidity in children with or without infection. Design: Children aged 5-10 y were recruited for a randomized, controlled, double-blind study from outpatients attending the Children's Hospital, Colombo, Sri Lanka. Clinical, inflammatory, nutritional, and iron statuses were determined at baseline and after the intervention. Children with a history of recurrent upper respiratory tract infections (URTIs) and with laboratory and clinical evidence of a current URTI constituted the infection group (n = 179), and children without infection constituted the control group (n = 184). Subjects in both groups were supplemented with ferrous sulfate (60 mg Fe) or placebo once daily for 8 wk. Morbidity from URTIs, the number of gastrointestinal infections, and compliance were recorded every 2 wk. Results: The overall prevalence of anemia was 52.6%. Iron supplementation significantly improved iron status by increasing hemoglobin (P < 0.001) and serum ferritin (P < 0.001) concentrations from baseline values in the children with or without infection. There was no significant improvement in iron status in the children who received placebo. In both the infection group and the control group, the mean number of URTI episodes and the total number of days sick with an URTI during the period of intervention were significantly lower (P < 0.005 and P < 0.001, respectively) in the children who received iron supplements than in those who received placebo. Conclusion: Iron supplementation significantly improves iron status and reduces morbidity from URTIs in children with or without infection.

Original languageEnglish (US)
Pages (from-to)234-241
Number of pages8
JournalAmerican Journal of Clinical Nutrition
Volume77
Issue number1
StatePublished - Jan 1 2003

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Sri Lanka
Respiratory Tract Infections
respiratory tract diseases
morbidity
Iron
iron
Morbidity
infection
Infection
placebos
ferrous sulfate
Placebos
Infection Control
Control Groups
iron deficiency anemia
Sick Leave
Iron-Deficiency Anemias
ferritin
socioeconomic status
Ferritins

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

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title = "Iron supplementation improves iron status and reduces morbidity in children with or without upper respiratory tract infections: A randomized controlled study in Colombo, Sri Lanka",
abstract = "Background: Iron deficiency anemia and recurrent infections are common among children of low socioeconomic status. Objective: The objective was to evaluate the effects of iron supplementation on iron status and morbidity in children with or without infection. Design: Children aged 5-10 y were recruited for a randomized, controlled, double-blind study from outpatients attending the Children's Hospital, Colombo, Sri Lanka. Clinical, inflammatory, nutritional, and iron statuses were determined at baseline and after the intervention. Children with a history of recurrent upper respiratory tract infections (URTIs) and with laboratory and clinical evidence of a current URTI constituted the infection group (n = 179), and children without infection constituted the control group (n = 184). Subjects in both groups were supplemented with ferrous sulfate (60 mg Fe) or placebo once daily for 8 wk. Morbidity from URTIs, the number of gastrointestinal infections, and compliance were recorded every 2 wk. Results: The overall prevalence of anemia was 52.6{\%}. Iron supplementation significantly improved iron status by increasing hemoglobin (P < 0.001) and serum ferritin (P < 0.001) concentrations from baseline values in the children with or without infection. There was no significant improvement in iron status in the children who received placebo. In both the infection group and the control group, the mean number of URTI episodes and the total number of days sick with an URTI during the period of intervention were significantly lower (P < 0.005 and P < 0.001, respectively) in the children who received iron supplements than in those who received placebo. Conclusion: Iron supplementation significantly improves iron status and reduces morbidity from URTIs in children with or without infection.",
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Iron supplementation improves iron status and reduces morbidity in children with or without upper respiratory tract infections : A randomized controlled study in Colombo, Sri Lanka. / De Silva, Angela; Atukorala, Sunethra; Weerasinghe, Irangani; Ahluwalia, Namanjeet.

In: American Journal of Clinical Nutrition, Vol. 77, No. 1, 01.01.2003, p. 234-241.

Research output: Contribution to journalArticle

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T1 - Iron supplementation improves iron status and reduces morbidity in children with or without upper respiratory tract infections

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N2 - Background: Iron deficiency anemia and recurrent infections are common among children of low socioeconomic status. Objective: The objective was to evaluate the effects of iron supplementation on iron status and morbidity in children with or without infection. Design: Children aged 5-10 y were recruited for a randomized, controlled, double-blind study from outpatients attending the Children's Hospital, Colombo, Sri Lanka. Clinical, inflammatory, nutritional, and iron statuses were determined at baseline and after the intervention. Children with a history of recurrent upper respiratory tract infections (URTIs) and with laboratory and clinical evidence of a current URTI constituted the infection group (n = 179), and children without infection constituted the control group (n = 184). Subjects in both groups were supplemented with ferrous sulfate (60 mg Fe) or placebo once daily for 8 wk. Morbidity from URTIs, the number of gastrointestinal infections, and compliance were recorded every 2 wk. Results: The overall prevalence of anemia was 52.6%. Iron supplementation significantly improved iron status by increasing hemoglobin (P < 0.001) and serum ferritin (P < 0.001) concentrations from baseline values in the children with or without infection. There was no significant improvement in iron status in the children who received placebo. In both the infection group and the control group, the mean number of URTI episodes and the total number of days sick with an URTI during the period of intervention were significantly lower (P < 0.005 and P < 0.001, respectively) in the children who received iron supplements than in those who received placebo. Conclusion: Iron supplementation significantly improves iron status and reduces morbidity from URTIs in children with or without infection.

AB - Background: Iron deficiency anemia and recurrent infections are common among children of low socioeconomic status. Objective: The objective was to evaluate the effects of iron supplementation on iron status and morbidity in children with or without infection. Design: Children aged 5-10 y were recruited for a randomized, controlled, double-blind study from outpatients attending the Children's Hospital, Colombo, Sri Lanka. Clinical, inflammatory, nutritional, and iron statuses were determined at baseline and after the intervention. Children with a history of recurrent upper respiratory tract infections (URTIs) and with laboratory and clinical evidence of a current URTI constituted the infection group (n = 179), and children without infection constituted the control group (n = 184). Subjects in both groups were supplemented with ferrous sulfate (60 mg Fe) or placebo once daily for 8 wk. Morbidity from URTIs, the number of gastrointestinal infections, and compliance were recorded every 2 wk. Results: The overall prevalence of anemia was 52.6%. Iron supplementation significantly improved iron status by increasing hemoglobin (P < 0.001) and serum ferritin (P < 0.001) concentrations from baseline values in the children with or without infection. There was no significant improvement in iron status in the children who received placebo. In both the infection group and the control group, the mean number of URTI episodes and the total number of days sick with an URTI during the period of intervention were significantly lower (P < 0.005 and P < 0.001, respectively) in the children who received iron supplements than in those who received placebo. Conclusion: Iron supplementation significantly improves iron status and reduces morbidity from URTIs in children with or without infection.

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