Is elimination of cyclosporine in bile dependent on liver graft function and biliary drainage?

Ashokkumar Jain, E. Elias, B. K. Gunson, J. A C Buckels, B. McDowell, A. Hillis, P. McMaster

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The aim of our study is to study the elimination of CsA by an assessment of its concentration in bile in relation to hepatic function, bile production, and the influence of other factors such as hepatic ischemia, phenytoin, and retransplantation. The rate of elimination of CsA in bile depends on hepatic function and the amount of bile produced. Sharp peak and trough levels of CsA in bile were not found as seen in blood or serum levels. However, when phenytoin is used, a marked increase in metabolism of the drug with both increase in parent compound and metabolites was noticed. Similarly, retransplant patients who were already on CsA before seem to reach their peak level in bile fairly soon.

Original languageEnglish (US)
Pages (from-to)516-522
Number of pages7
JournalTransplantation Proceedings
Volume20
Issue number2 SUPPL. 2
StatePublished - 1988

Fingerprint

Bile
Cyclosporine
Drainage
Transplants
Liver
Phenytoin
Ischemia
Serum
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Surgery
  • Transplantation

Cite this

Jain, A., Elias, E., Gunson, B. K., Buckels, J. A. C., McDowell, B., Hillis, A., & McMaster, P. (1988). Is elimination of cyclosporine in bile dependent on liver graft function and biliary drainage? Transplantation Proceedings, 20(2 SUPPL. 2), 516-522.
Jain, Ashokkumar ; Elias, E. ; Gunson, B. K. ; Buckels, J. A C ; McDowell, B. ; Hillis, A. ; McMaster, P. / Is elimination of cyclosporine in bile dependent on liver graft function and biliary drainage?. In: Transplantation Proceedings. 1988 ; Vol. 20, No. 2 SUPPL. 2. pp. 516-522.
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Jain, A, Elias, E, Gunson, BK, Buckels, JAC, McDowell, B, Hillis, A & McMaster, P 1988, 'Is elimination of cyclosporine in bile dependent on liver graft function and biliary drainage?', Transplantation Proceedings, vol. 20, no. 2 SUPPL. 2, pp. 516-522.

Is elimination of cyclosporine in bile dependent on liver graft function and biliary drainage? / Jain, Ashokkumar; Elias, E.; Gunson, B. K.; Buckels, J. A C; McDowell, B.; Hillis, A.; McMaster, P.

In: Transplantation Proceedings, Vol. 20, No. 2 SUPPL. 2, 1988, p. 516-522.

Research output: Contribution to journalArticle

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AB - The aim of our study is to study the elimination of CsA by an assessment of its concentration in bile in relation to hepatic function, bile production, and the influence of other factors such as hepatic ischemia, phenytoin, and retransplantation. The rate of elimination of CsA in bile depends on hepatic function and the amount of bile produced. Sharp peak and trough levels of CsA in bile were not found as seen in blood or serum levels. However, when phenytoin is used, a marked increase in metabolism of the drug with both increase in parent compound and metabolites was noticed. Similarly, retransplant patients who were already on CsA before seem to reach their peak level in bile fairly soon.

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Jain A, Elias E, Gunson BK, Buckels JAC, McDowell B, Hillis A et al. Is elimination of cyclosporine in bile dependent on liver graft function and biliary drainage? Transplantation Proceedings. 1988;20(2 SUPPL. 2):516-522.