Is (poly-) substance use associated with impaired inhibitory control? A mega-analysis controlling for confounders

Yang Liu; Wery P.M. van den Wildenberg; Ysanne de Graaf; Susan L. Ames; Alexander Baldacchino; Ragnhild Bø; Fernando Cadaveira; Salvatore Campanella; Paul Christiansen; Eric D. Claus; Lorenza S. Colzato; Francesca M. Filbey; John J. Foxe; Hugh Garavan; Christian S. Hendershot; Robert Hester; Jennifer M. Jester; Hollis C. Karoly; Anja Kräplin; Fanny Kreusch; Nils Inge Landrø; Marianne Littel; Sabine Loeber; Edythe D. London; Eduardo López-Caneda; Dan I. Lubman; Maartje Luijten; Cecile A. Marczinski; Jane Metrik; Catharine Montgomery; Harilaos Papachristou; Su Mi Park; Andres L. Paz; Géraldine Petit; James J. Prisciandaro; Boris B. Quednow; Lara A. Ray; Carl A. Roberts; Gloria M.P. Roberts; Michiel B. de Ruiter; Claudia I. Rupp; Vaughn R. Steele; Delin Sun; Michael Takagi; Susan F. Tapert; Ruth J. van Holst; Antonio Verdejo-Garcia; Matthias Vonmoos; Marcin Wojnar; Yuanwei Yao; Murat Yücel; Martin Zack; Robert A. Zucker; Hilde M. Huizenga; Reinout W. Wiers

doi:10.1016/j.neubiorev.2019.07.006

Is (poly-) substance use associated with impaired inhibitory control? A mega-analysis controlling for confounders

Yang Liu, Wery P.M. van den Wildenberg, Ysanne de Graaf, Susan L. Ames, Alexander Baldacchino, Ragnhild Bø, Fernando Cadaveira, Salvatore Campanella, Paul Christiansen, Eric D. Claus, Lorenza S. Colzato, Francesca M. Filbey, John J. Foxe, Hugh Garavan, Christian S. Hendershot, Robert Hester, Jennifer M. Jester, Hollis C. Karoly, Anja Kräplin, Fanny KreuschNils Inge Landrø, Marianne Littel, Sabine Loeber, Edythe D. London, Eduardo López-Caneda, Dan I. Lubman, Maartje Luijten, Cecile A. Marczinski, Jane Metrik, Catharine Montgomery, Harilaos Papachristou, Su Mi Park, Andres L. Paz, Géraldine Petit, James J. Prisciandaro, Boris B. Quednow, Lara A. Ray, Carl A. Roberts, Gloria M.P. Roberts, Michiel B. de Ruiter, Claudia I. Rupp, Vaughn R. Steele, Delin Sun, Michael Takagi, Susan F. Tapert, Ruth J. van Holst, Antonio Verdejo-Garcia, Matthias Vonmoos, Marcin Wojnar, Yuanwei Yao, Murat Yücel, Martin Zack, Robert A. Zucker, Hilde M. Huizenga, Reinout W. Wiers

Research output: Contribution to journal › Review article › peer-review

33 Scopus citations

Abstract

Many studies have reported that heavy substance use is associated with impaired response inhibition. Studies typically focused on associations with a single substance, while polysubstance use is common. Further, most studies compared heavy users with light/non-users, though substance use occurs along a continuum. The current mega-analysis accounted for these issues by aggregating individual data from 43 studies (3610 adult participants) that used the Go/No-Go (GNG) or Stop-signal task (SST) to assess inhibition among mostly “recreational” substance users (i.e., the rate of substance use disorders was low). Main and interaction effects of substance use, demographics, and task-characteristics were entered in a linear mixed model. Contrary to many studies and reviews in the field, we found that only lifetime cannabis use was associated with impaired response inhibition in the SST. An interaction effect was also observed: the relationship between tobacco use and response inhibition (in the SST) differed between cannabis users and non-users, with a negative association between tobacco use and inhibition in the cannabis non-users. In addition, participants’ age, education level, and some task characteristics influenced inhibition outcomes. Overall, we found limited support for impaired inhibition among substance users when controlling for demographics and task-characteristics.

Original language	English (US)
Pages (from-to)	288-304
Number of pages	17
Journal	Neuroscience and Biobehavioral Reviews
Volume	105
DOIs	https://doi.org/10.1016/j.neubiorev.2019.07.006
State	Published - Oct 2019

All Science Journal Classification (ASJC) codes

Neuropsychology and Physiological Psychology
Cognitive Neuroscience
Behavioral Neuroscience

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10.1016/j.neubiorev.2019.07.006

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Liu, Y., van den Wildenberg, W. P. M., de Graaf, Y., Ames, S. L., Baldacchino, A., Bø, R., Cadaveira, F., Campanella, S., Christiansen, P., Claus, E. D., Colzato, L. S., Filbey, F. M., Foxe, J. J., Garavan, H., Hendershot, C. S., Hester, R., Jester, J. M., Karoly, H. C., Kräplin, A., ... Wiers, R. W. (2019). Is (poly-) substance use associated with impaired inhibitory control? A mega-analysis controlling for confounders. Neuroscience and Biobehavioral Reviews, 105, 288-304. https://doi.org/10.1016/j.neubiorev.2019.07.006

@article{19cad522b8bf4d68bdee51e1f80fb169,

title = "Is (poly-) substance use associated with impaired inhibitory control? A mega-analysis controlling for confounders",

abstract = "Many studies have reported that heavy substance use is associated with impaired response inhibition. Studies typically focused on associations with a single substance, while polysubstance use is common. Further, most studies compared heavy users with light/non-users, though substance use occurs along a continuum. The current mega-analysis accounted for these issues by aggregating individual data from 43 studies (3610 adult participants) that used the Go/No-Go (GNG) or Stop-signal task (SST) to assess inhibition among mostly “recreational” substance users (i.e., the rate of substance use disorders was low). Main and interaction effects of substance use, demographics, and task-characteristics were entered in a linear mixed model. Contrary to many studies and reviews in the field, we found that only lifetime cannabis use was associated with impaired response inhibition in the SST. An interaction effect was also observed: the relationship between tobacco use and response inhibition (in the SST) differed between cannabis users and non-users, with a negative association between tobacco use and inhibition in the cannabis non-users. In addition, participants{\textquoteright} age, education level, and some task characteristics influenced inhibition outcomes. Overall, we found limited support for impaired inhibition among substance users when controlling for demographics and task-characteristics.",

author = "Yang Liu and {van den Wildenberg}, {Wery P.M.} and {de Graaf}, Ysanne and Ames, {Susan L.} and Alexander Baldacchino and Ragnhild B{\o} and Fernando Cadaveira and Salvatore Campanella and Paul Christiansen and Claus, {Eric D.} and Colzato, {Lorenza S.} and Filbey, {Francesca M.} and Foxe, {John J.} and Hugh Garavan and Hendershot, {Christian S.} and Robert Hester and Jester, {Jennifer M.} and Karoly, {Hollis C.} and Anja Kr{\"a}plin and Fanny Kreusch and Landr{\o}, {Nils Inge} and Marianne Littel and Sabine Loeber and London, {Edythe D.} and Eduardo L{\'o}pez-Caneda and Lubman, {Dan I.} and Maartje Luijten and Marczinski, {Cecile A.} and Jane Metrik and Catharine Montgomery and Harilaos Papachristou and {Mi Park}, Su and Paz, {Andres L.} and G{\'e}raldine Petit and Prisciandaro, {James J.} and Quednow, {Boris B.} and Ray, {Lara A.} and Roberts, {Carl A.} and Roberts, {Gloria M.P.} and {de Ruiter}, {Michiel B.} and Rupp, {Claudia I.} and Steele, {Vaughn R.} and Delin Sun and Michael Takagi and Tapert, {Susan F.} and {van Holst}, {Ruth J.} and Antonio Verdejo-Garcia and Matthias Vonmoos and Marcin Wojnar and Yuanwei Yao and Murat Y{\"u}cel and Martin Zack and Zucker, {Robert A.} and Huizenga, {Hilde M.} and Wiers, {Reinout W.}",

note = "Funding Information: HMH is supported by a VICI grant awarded by the Netherlands Organization of Scientific Research (NWO) [grant number 453-12-005] Funding Information: MY was supported by a National Health and Medical Research Council of Australia Fellowship ( #APP1117188 ) and the David Winston Turner Endowment Fund . Funding Information: China scholarship council (CSC) (No. 201506990019).VICI grant awarded by the Netherlands Organization of Scientific Research (NWO) [grant number 453-12-005].We thank Janneke Staaks at the library of the University of Amsterdam for providing support for the literature search. We thank Dr. Jorien Treur for her feedback on the manuscript. We thank Lauren Kuhns for her proofreading. We thank Dr. Rebecca L. Ashare, Dr. Elliot T. Berkman, Dr. Craig R. Colder, Dr. Pike Erika, Dr. Mark T. Fillmore, Dr. Rual Gonzalez, Dr. Bernice Porjesz, Dr. Olga Rass, and Dr. Craig R. Rush who contributed raw data without co-authorship. Yang Liu thanks the China scholarship council (CSC) (No. 201506990019) for fellowship support. HMH is supported by a VICI grant awarded by the Netherlands Organization of Scientific Research (NWO) [grant number 453-12-005], MY was supported by a National Health and Medical Research Council of Australia Fellowship (#APP1117188) and the David Winston Turner Endowment Fund. Funding Information: VICI grant awarded by the Netherlands Organization of Scientific Research (NWO) [grant number 453-12-005 ]. Funding Information: Yang Liu thanks the China scholarship council (CSC) (No. 201506990019) for fellowship support. Publisher Copyright: {\textcopyright} 2019 The Authors",

year = "2019",

month = oct,

doi = "10.1016/j.neubiorev.2019.07.006",

language = "English (US)",

volume = "105",

pages = "288--304",

journal = "Neuroscience and Biobehavioral Reviews",

issn = "0149-7634",

publisher = "Elsevier Limited",

}

Liu, Y, van den Wildenberg, WPM, de Graaf, Y, Ames, SL, Baldacchino, A, Bø, R, Cadaveira, F, Campanella, S, Christiansen, P, Claus, ED, Colzato, LS, Filbey, FM, Foxe, JJ, Garavan, H, Hendershot, CS, Hester, R, Jester, JM, Karoly, HC, Kräplin, A, Kreusch, F, Landrø, NI, Littel, M, Loeber, S, London, ED, López-Caneda, E, Lubman, DI, Luijten, M, Marczinski, CA, Metrik, J, Montgomery, C, Papachristou, H, Mi Park, S, Paz, AL, Petit, G, Prisciandaro, JJ, Quednow, BB, Ray, LA, Roberts, CA, Roberts, GMP, de Ruiter, MB, Rupp, CI, Steele, VR, Sun, D, Takagi, M, Tapert, SF, van Holst, RJ, Verdejo-Garcia, A, Vonmoos, M, Wojnar, M, Yao, Y, Yücel, M, Zack, M, Zucker, RA, Huizenga, HM & Wiers, RW 2019, 'Is (poly-) substance use associated with impaired inhibitory control? A mega-analysis controlling for confounders', Neuroscience and Biobehavioral Reviews, vol. 105, pp. 288-304. https://doi.org/10.1016/j.neubiorev.2019.07.006

TY - JOUR

T1 - Is (poly-) substance use associated with impaired inhibitory control? A mega-analysis controlling for confounders

AU - Liu, Yang

AU - van den Wildenberg, Wery P.M.

AU - de Graaf, Ysanne

AU - Ames, Susan L.

AU - Baldacchino, Alexander

AU - Bø, Ragnhild

AU - Cadaveira, Fernando

AU - Campanella, Salvatore

AU - Christiansen, Paul

AU - Claus, Eric D.

AU - Colzato, Lorenza S.

AU - Filbey, Francesca M.

AU - Foxe, John J.

AU - Garavan, Hugh

AU - Hendershot, Christian S.

AU - Hester, Robert

AU - Jester, Jennifer M.

AU - Karoly, Hollis C.

AU - Kräplin, Anja

AU - Kreusch, Fanny

AU - Landrø, Nils Inge

AU - Littel, Marianne

AU - Loeber, Sabine

AU - London, Edythe D.

AU - López-Caneda, Eduardo

AU - Lubman, Dan I.

AU - Luijten, Maartje

AU - Marczinski, Cecile A.

AU - Metrik, Jane

AU - Montgomery, Catharine

AU - Papachristou, Harilaos

AU - Mi Park, Su

AU - Paz, Andres L.

AU - Petit, Géraldine

AU - Prisciandaro, James J.

AU - Quednow, Boris B.

AU - Ray, Lara A.

AU - Roberts, Carl A.

AU - Roberts, Gloria M.P.

AU - de Ruiter, Michiel B.

AU - Rupp, Claudia I.

AU - Steele, Vaughn R.

AU - Sun, Delin

AU - Takagi, Michael

AU - Tapert, Susan F.

AU - van Holst, Ruth J.

AU - Verdejo-Garcia, Antonio

AU - Vonmoos, Matthias

AU - Wojnar, Marcin

AU - Yao, Yuanwei

AU - Yücel, Murat

AU - Zack, Martin

AU - Zucker, Robert A.

AU - Huizenga, Hilde M.

AU - Wiers, Reinout W.

N1 - Funding Information: HMH is supported by a VICI grant awarded by the Netherlands Organization of Scientific Research (NWO) [grant number 453-12-005] Funding Information: MY was supported by a National Health and Medical Research Council of Australia Fellowship ( #APP1117188 ) and the David Winston Turner Endowment Fund . Funding Information: China scholarship council (CSC) (No. 201506990019).VICI grant awarded by the Netherlands Organization of Scientific Research (NWO) [grant number 453-12-005].We thank Janneke Staaks at the library of the University of Amsterdam for providing support for the literature search. We thank Dr. Jorien Treur for her feedback on the manuscript. We thank Lauren Kuhns for her proofreading. We thank Dr. Rebecca L. Ashare, Dr. Elliot T. Berkman, Dr. Craig R. Colder, Dr. Pike Erika, Dr. Mark T. Fillmore, Dr. Rual Gonzalez, Dr. Bernice Porjesz, Dr. Olga Rass, and Dr. Craig R. Rush who contributed raw data without co-authorship. Yang Liu thanks the China scholarship council (CSC) (No. 201506990019) for fellowship support. HMH is supported by a VICI grant awarded by the Netherlands Organization of Scientific Research (NWO) [grant number 453-12-005], MY was supported by a National Health and Medical Research Council of Australia Fellowship (#APP1117188) and the David Winston Turner Endowment Fund. Funding Information: VICI grant awarded by the Netherlands Organization of Scientific Research (NWO) [grant number 453-12-005 ]. Funding Information: Yang Liu thanks the China scholarship council (CSC) (No. 201506990019) for fellowship support. Publisher Copyright: © 2019 The Authors

PY - 2019/10

Y1 - 2019/10

N2 - Many studies have reported that heavy substance use is associated with impaired response inhibition. Studies typically focused on associations with a single substance, while polysubstance use is common. Further, most studies compared heavy users with light/non-users, though substance use occurs along a continuum. The current mega-analysis accounted for these issues by aggregating individual data from 43 studies (3610 adult participants) that used the Go/No-Go (GNG) or Stop-signal task (SST) to assess inhibition among mostly “recreational” substance users (i.e., the rate of substance use disorders was low). Main and interaction effects of substance use, demographics, and task-characteristics were entered in a linear mixed model. Contrary to many studies and reviews in the field, we found that only lifetime cannabis use was associated with impaired response inhibition in the SST. An interaction effect was also observed: the relationship between tobacco use and response inhibition (in the SST) differed between cannabis users and non-users, with a negative association between tobacco use and inhibition in the cannabis non-users. In addition, participants’ age, education level, and some task characteristics influenced inhibition outcomes. Overall, we found limited support for impaired inhibition among substance users when controlling for demographics and task-characteristics.

AB - Many studies have reported that heavy substance use is associated with impaired response inhibition. Studies typically focused on associations with a single substance, while polysubstance use is common. Further, most studies compared heavy users with light/non-users, though substance use occurs along a continuum. The current mega-analysis accounted for these issues by aggregating individual data from 43 studies (3610 adult participants) that used the Go/No-Go (GNG) or Stop-signal task (SST) to assess inhibition among mostly “recreational” substance users (i.e., the rate of substance use disorders was low). Main and interaction effects of substance use, demographics, and task-characteristics were entered in a linear mixed model. Contrary to many studies and reviews in the field, we found that only lifetime cannabis use was associated with impaired response inhibition in the SST. An interaction effect was also observed: the relationship between tobacco use and response inhibition (in the SST) differed between cannabis users and non-users, with a negative association between tobacco use and inhibition in the cannabis non-users. In addition, participants’ age, education level, and some task characteristics influenced inhibition outcomes. Overall, we found limited support for impaired inhibition among substance users when controlling for demographics and task-characteristics.

UR - http://www.scopus.com/inward/record.url?scp=85070721793&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85070721793&partnerID=8YFLogxK

U2 - 10.1016/j.neubiorev.2019.07.006

DO - 10.1016/j.neubiorev.2019.07.006

M3 - Review article

C2 - 31319124

AN - SCOPUS:85070721793

SN - 0149-7634

VL - 105

SP - 288

EP - 304

JO - Neuroscience and Biobehavioral Reviews

JF - Neuroscience and Biobehavioral Reviews

ER -

Is (poly-) substance use associated with impaired inhibitory control? A mega-analysis controlling for confounders

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