Ischemia‐Induced depressed systolic thickening is transiently augmented by remote coronary occlusion

Joseph Gascho, Gary L. Copenhaver, William Davidson

Research output: Contribution to journalArticle

Abstract

To determine if ischemia‐induced depressed myocardial thickening can be augmented by remote coronary occlusion, posterior wall function (pulsed Doppler crystal) was measured before and after left anterior descending coronary artery occlusion in the presence of reduced circumflex coronary artery flow (of sufficient severity to reduce resting function) in an anesthetized open‐chest canine preparation in which the circumflex was pump‐perfused with carotid arterial blood. Left anterior descending coronary occlusion elicited an immediate significant increase in posterior bed thickening fraction (TF%) (3.7 ± 1.5 to 5.9 ± 1.3%), but by 135 sec TF% had again deteriorated. The transient increase in thickening was not caused by increased flow to the posterior bed (microspheres, n = 3), nor was it related to a Frank‐Starling mechanism (echocardiography, n = 3). Despite an ischemic‐induced reduction in systolic shortening, systolic thickening can be transiently augmented by remote coronary occlusion. The etiology may be related to systolic unloading.

Original languageEnglish (US)
Pages (from-to)253-259
Number of pages7
JournalCatheterization and Cardiovascular Diagnosis
Volume25
Issue number3
DOIs
StatePublished - Jan 1 1992

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Coronary Occlusion
Coronary Vessels
Microspheres
Echocardiography
Canidae

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

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title = "Ischemia‐Induced depressed systolic thickening is transiently augmented by remote coronary occlusion",
abstract = "To determine if ischemia‐induced depressed myocardial thickening can be augmented by remote coronary occlusion, posterior wall function (pulsed Doppler crystal) was measured before and after left anterior descending coronary artery occlusion in the presence of reduced circumflex coronary artery flow (of sufficient severity to reduce resting function) in an anesthetized open‐chest canine preparation in which the circumflex was pump‐perfused with carotid arterial blood. Left anterior descending coronary occlusion elicited an immediate significant increase in posterior bed thickening fraction (TF{\%}) (3.7 ± 1.5 to 5.9 ± 1.3{\%}), but by 135 sec TF{\%} had again deteriorated. The transient increase in thickening was not caused by increased flow to the posterior bed (microspheres, n = 3), nor was it related to a Frank‐Starling mechanism (echocardiography, n = 3). Despite an ischemic‐induced reduction in systolic shortening, systolic thickening can be transiently augmented by remote coronary occlusion. The etiology may be related to systolic unloading.",
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Ischemia‐Induced depressed systolic thickening is transiently augmented by remote coronary occlusion. / Gascho, Joseph; Copenhaver, Gary L.; Davidson, William.

In: Catheterization and Cardiovascular Diagnosis, Vol. 25, No. 3, 01.01.1992, p. 253-259.

Research output: Contribution to journalArticle

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