Ischemically sensitive abdominal visceral afferents

Response to cyclooxygenase blockade

J. C. Longhurst, D. M. Rotto, Marc Kaufman, G. L. Stahl

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Ischemically sensitive abdominal visceral afferents are known to reflexly stimulate the cardiovascular system. These nerve endings respond to severe hypoxia as well as to exogenously administered bradykinin and prostaglandins such as PGI2, PGE, and PGF(2α). We have shown previously that these prostaglandins can sensitize some previously unresponsive afferents to respond to ischemia. To determine if endogenously produced prostaglandins contribute to the observed increase in activity during ischemia, we recorded activity of 6 Aδ- and 23 C-fiber sympathetic afferents in anesthetized cats during 5 min of ischemia before and 15-30 min after intravenous administration of either indomethacin (5 mg/kg) or aspirin (50 mg/kg). Before cyclooxygenase inhibition, we noted repeatable increases of 1.44 ± 0.22 and 1.44 ± 0.36 impulses/s in the Aδ- and C-fibers, respectively, in response to ischemia. After indomethacin or aspirin, these increases were significantly reduced (P < 0.05) in both thinly myelinated and unmyelinated afferents (0.69 ± 0.36 and 0.46 ± 0.21 impulses/s, respectively). In a second protocol, we observed that the activity of six Aδ- and seven C-fibers was significantly reduced by aspirin or indomethacin when a single period of ischemia preceded cyclooxygenase blockade. These data, in conjunction with our previous observations, indicate that prostaglandins significantly contribute to the increased afferent discharge activity associated with ischemia of the abdominal visceral region.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Heart and Circulatory Physiology
Volume261
Issue number6 30-6
StatePublished - 1991

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Visceral Afferents
Prostaglandin-Endoperoxide Synthases
Ischemia
Unmyelinated Nerve Fibers
Prostaglandins
Indomethacin
Aspirin
Nerve Endings
Prostaglandins F
Bradykinin
Epoprostenol
Cardiovascular System
Prostaglandins E
Intravenous Administration
Cats

All Science Journal Classification (ASJC) codes

  • Physiology

Cite this

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title = "Ischemically sensitive abdominal visceral afferents: Response to cyclooxygenase blockade",
abstract = "Ischemically sensitive abdominal visceral afferents are known to reflexly stimulate the cardiovascular system. These nerve endings respond to severe hypoxia as well as to exogenously administered bradykinin and prostaglandins such as PGI2, PGE, and PGF(2α). We have shown previously that these prostaglandins can sensitize some previously unresponsive afferents to respond to ischemia. To determine if endogenously produced prostaglandins contribute to the observed increase in activity during ischemia, we recorded activity of 6 Aδ- and 23 C-fiber sympathetic afferents in anesthetized cats during 5 min of ischemia before and 15-30 min after intravenous administration of either indomethacin (5 mg/kg) or aspirin (50 mg/kg). Before cyclooxygenase inhibition, we noted repeatable increases of 1.44 ± 0.22 and 1.44 ± 0.36 impulses/s in the Aδ- and C-fibers, respectively, in response to ischemia. After indomethacin or aspirin, these increases were significantly reduced (P < 0.05) in both thinly myelinated and unmyelinated afferents (0.69 ± 0.36 and 0.46 ± 0.21 impulses/s, respectively). In a second protocol, we observed that the activity of six Aδ- and seven C-fibers was significantly reduced by aspirin or indomethacin when a single period of ischemia preceded cyclooxygenase blockade. These data, in conjunction with our previous observations, indicate that prostaglandins significantly contribute to the increased afferent discharge activity associated with ischemia of the abdominal visceral region.",
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Ischemically sensitive abdominal visceral afferents : Response to cyclooxygenase blockade. / Longhurst, J. C.; Rotto, D. M.; Kaufman, Marc; Stahl, G. L.

In: American Journal of Physiology - Heart and Circulatory Physiology, Vol. 261, No. 6 30-6, 1991.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Ischemically sensitive abdominal visceral afferents

T2 - Response to cyclooxygenase blockade

AU - Longhurst, J. C.

AU - Rotto, D. M.

AU - Kaufman, Marc

AU - Stahl, G. L.

PY - 1991

Y1 - 1991

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