Isolation of pure compound R/J/3 from Pluchea indica (L.) Less. and its anti-amoebic activities against Entamoeba histolytica

Ria Biswas, P. K. Dutta, B. Achari, Durba Bandyopadhyay, Moumita Mishra, Kartick Pramanik, T. K. Chatterjee

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Abstract

The plant Pluchea indica is known for its anti-inflammatory, anti-ulcer, anti-pyretic, hypoglycemic, diuretic and anti-microbial activities besides many other pharmacological activities. We have isolated and purified seven compounds from the methanolic root extract of this plant by column chromatography. The compounds were identified by spectroscopic analyses. The anti-amoebic activities of the pure compound R/J/3 was investigated against the HM1 strain of Entamoeba histolytica. The compound, R/J/3 showed the most pronounced anti-proliferative activity at a dose of 50 μg/ml. It also showed a marked activity on cell lysis of trophozoites, 4 h after administration. The cell lytic activity was compared with metronidazole (5 μg/ml) as positive control.

Original languageEnglish (US)
Pages (from-to)534-537
Number of pages4
JournalPhytomedicine
Volume14
Issue number7-8
DOIs
Publication statusPublished - Aug 6 2007

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All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine

Cite this

Biswas, R., Dutta, P. K., Achari, B., Bandyopadhyay, D., Mishra, M., Pramanik, K., & Chatterjee, T. K. (2007). Isolation of pure compound R/J/3 from Pluchea indica (L.) Less. and its anti-amoebic activities against Entamoeba histolytica. Phytomedicine, 14(7-8), 534-537. https://doi.org/10.1016/j.phymed.2006.11.003