Isolation of pure compound R/J/3 from Pluchea indica (L.) Less. and its anti-amoebic activities against Entamoeba histolytica

Ria Biswas; P. K. Dutta; B. Achari; Durba Bandyopadhyay; Moumita Mishra; Kartick Pramanik; T. K. Chatterjee

doi:10.1016/j.phymed.2006.11.003

Isolation of pure compound R/J/3 from Pluchea indica (L.) Less. and its anti-amoebic activities against Entamoeba histolytica

Ria Biswas, P. K. Dutta, B. Achari, Durba Bandyopadhyay, Moumita Mishra, Kartick Pramanik, T. K. Chatterjee

Department of Pharmacology

Research output: Contribution to journal › Article

18 Scopus citations

Abstract

The plant Pluchea indica is known for its anti-inflammatory, anti-ulcer, anti-pyretic, hypoglycemic, diuretic and anti-microbial activities besides many other pharmacological activities. We have isolated and purified seven compounds from the methanolic root extract of this plant by column chromatography. The compounds were identified by spectroscopic analyses. The anti-amoebic activities of the pure compound R/J/3 was investigated against the HM1 strain of Entamoeba histolytica. The compound, R/J/3 showed the most pronounced anti-proliferative activity at a dose of 50 μg/ml. It also showed a marked activity on cell lysis of trophozoites, 4 h after administration. The cell lytic activity was compared with metronidazole (5 μg/ml) as positive control.

Original language	English (US)
Pages (from-to)	534-537
Number of pages	4
Journal	Phytomedicine
Volume	14
Issue number	7-8
DOIs	https://doi.org/10.1016/j.phymed.2006.11.003
Publication status	Published - Aug 6 2007

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All Science Journal Classification (ASJC) codes

Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine

Cite this

Biswas, R., Dutta, P. K., Achari, B., Bandyopadhyay, D., Mishra, M., Pramanik, K., & Chatterjee, T. K. (2007). Isolation of pure compound R/J/3 from Pluchea indica (L.) Less. and its anti-amoebic activities against Entamoeba histolytica. Phytomedicine, 14(7-8), 534-537. https://doi.org/10.1016/j.phymed.2006.11.003

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abstract = "The plant Pluchea indica is known for its anti-inflammatory, anti-ulcer, anti-pyretic, hypoglycemic, diuretic and anti-microbial activities besides many other pharmacological activities. We have isolated and purified seven compounds from the methanolic root extract of this plant by column chromatography. The compounds were identified by spectroscopic analyses. The anti-amoebic activities of the pure compound R/J/3 was investigated against the HM1 strain of Entamoeba histolytica. The compound, R/J/3 showed the most pronounced anti-proliferative activity at a dose of 50 μg/ml. It also showed a marked activity on cell lysis of trophozoites, 4 h after administration. The cell lytic activity was compared with metronidazole (5 μg/ml) as positive control.",

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AU - Achari, B.

AU - Bandyopadhyay, Durba

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AB - The plant Pluchea indica is known for its anti-inflammatory, anti-ulcer, anti-pyretic, hypoglycemic, diuretic and anti-microbial activities besides many other pharmacological activities. We have isolated and purified seven compounds from the methanolic root extract of this plant by column chromatography. The compounds were identified by spectroscopic analyses. The anti-amoebic activities of the pure compound R/J/3 was investigated against the HM1 strain of Entamoeba histolytica. The compound, R/J/3 showed the most pronounced anti-proliferative activity at a dose of 50 μg/ml. It also showed a marked activity on cell lysis of trophozoites, 4 h after administration. The cell lytic activity was compared with metronidazole (5 μg/ml) as positive control.

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10.1016/j.phymed.2006.11.003