Isolation, structure elucidation, and biological evaluation of 15-amido-3-demethoxy-2α,3α-methylenedioxyerythroculine, a new alkaloid from Hyperbaena valida

Alan J. Freyer, Justin Huffman, Mary D. Menachery, Kristina Huey, William J. Leavens, Richard W. Fitch

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

A phytochemical investigation of the leaves of Hyperbaena valida resulted in the isolation and characterization of two erythrina-type alkaloids, 1 and 2, which were found to be antagonists at nicotinic receptors. Compound 1 was assigned as the new 15-amido-3-demethoxy-2α,3α- methylenedioxyerythroculine and compound 2 as the known 3-demethoxy-2α, 3α-methylenedioxyerythroculine. Antagonism of a 100 μM nicotine response was observed for alkaloid 1 (IC50 value of 94 ± 8 μM) and alkaloid 2 (IC50 value of 77 ± 19 μM).

Original languageEnglish (US)
Pages (from-to)1514-1516
Number of pages3
JournalJournal of Natural Products
Volume69
Issue number10
DOIs
StatePublished - Oct 1 2006

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Complementary and alternative medicine
  • Organic Chemistry

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