A phytochemical investigation of the leaves of Hyperbaena valida resulted in the isolation and characterization of two erythrina-type alkaloids, 1 and 2, which were found to be antagonists at nicotinic receptors. Compound 1 was assigned as the new 15-amido-3-demethoxy-2α,3α- methylenedioxyerythroculine and compound 2 as the known 3-demethoxy-2α, 3α-methylenedioxyerythroculine. Antagonism of a 100 μM nicotine response was observed for alkaloid 1 (IC50 value of 94 ± 8 μM) and alkaloid 2 (IC50 value of 77 ± 19 μM).
All Science Journal Classification (ASJC) codes
- Analytical Chemistry
- Molecular Medicine
- Pharmaceutical Science
- Drug Discovery
- Complementary and alternative medicine
- Organic Chemistry