Isoprenoids: Remarkable diversity of form and function

Sarah A. Holstein, Raymond J. Hohl

Research output: Contribution to journalReview article

118 Citations (Scopus)

Abstract

The isoprenoid biosynthetic pathway is the source of a wide array of products. The pathway has been highly conserved throughout evolution, and isoprenoids are some of the most ancient biomolecules ever identified, playing key roles in many life forms. In this review we focus on C-10 mono-, C-15 sesqui-, and C-20 diterpenes. Evidence for interconversion between the pathway intermediates farnesyl pyrophosphate and geranylgeranyl pyrophosphate and their respective metabolites is examined. The diverse functions of these molecules are discussed in detail, including their ability to regulate expression of the β-HMG-CoA reductase and Ras-related proteins. Additional topics include the mechanisms underlying the apoptotic effects of select isoprenoids, antiulcer activities, and the disposition and degradation of isoprenoids in the environment. Finally, the significance of pharmacological manipulation of the isoprenoid pathway and clinical correlations are discussed.

Original languageEnglish (US)
Pages (from-to)293-309
Number of pages17
JournalLipids
Volume39
Issue number4
DOIs
StatePublished - Apr 1 2004

Fingerprint

Terpenes
Hydroxymethylglutaryl CoA Reductases
ras Proteins
Critical Pathways
Diterpenes
Biosynthetic Pathways
Biomolecules
Metabolites
Pharmacology
Degradation
Molecules
Proteins

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Organic Chemistry
  • Cell Biology

Cite this

Holstein, Sarah A. ; Hohl, Raymond J. / Isoprenoids : Remarkable diversity of form and function. In: Lipids. 2004 ; Vol. 39, No. 4. pp. 293-309.
@article{181a710243e94ed48268dc451cfc1add,
title = "Isoprenoids: Remarkable diversity of form and function",
abstract = "The isoprenoid biosynthetic pathway is the source of a wide array of products. The pathway has been highly conserved throughout evolution, and isoprenoids are some of the most ancient biomolecules ever identified, playing key roles in many life forms. In this review we focus on C-10 mono-, C-15 sesqui-, and C-20 diterpenes. Evidence for interconversion between the pathway intermediates farnesyl pyrophosphate and geranylgeranyl pyrophosphate and their respective metabolites is examined. The diverse functions of these molecules are discussed in detail, including their ability to regulate expression of the β-HMG-CoA reductase and Ras-related proteins. Additional topics include the mechanisms underlying the apoptotic effects of select isoprenoids, antiulcer activities, and the disposition and degradation of isoprenoids in the environment. Finally, the significance of pharmacological manipulation of the isoprenoid pathway and clinical correlations are discussed.",
author = "Holstein, {Sarah A.} and Hohl, {Raymond J.}",
year = "2004",
month = "4",
day = "1",
doi = "10.1007/s11745-004-1233-3",
language = "English (US)",
volume = "39",
pages = "293--309",
journal = "Lipids",
issn = "0024-4201",
publisher = "Springer Verlag",
number = "4",

}

Isoprenoids : Remarkable diversity of form and function. / Holstein, Sarah A.; Hohl, Raymond J.

In: Lipids, Vol. 39, No. 4, 01.04.2004, p. 293-309.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Isoprenoids

T2 - Remarkable diversity of form and function

AU - Holstein, Sarah A.

AU - Hohl, Raymond J.

PY - 2004/4/1

Y1 - 2004/4/1

N2 - The isoprenoid biosynthetic pathway is the source of a wide array of products. The pathway has been highly conserved throughout evolution, and isoprenoids are some of the most ancient biomolecules ever identified, playing key roles in many life forms. In this review we focus on C-10 mono-, C-15 sesqui-, and C-20 diterpenes. Evidence for interconversion between the pathway intermediates farnesyl pyrophosphate and geranylgeranyl pyrophosphate and their respective metabolites is examined. The diverse functions of these molecules are discussed in detail, including their ability to regulate expression of the β-HMG-CoA reductase and Ras-related proteins. Additional topics include the mechanisms underlying the apoptotic effects of select isoprenoids, antiulcer activities, and the disposition and degradation of isoprenoids in the environment. Finally, the significance of pharmacological manipulation of the isoprenoid pathway and clinical correlations are discussed.

AB - The isoprenoid biosynthetic pathway is the source of a wide array of products. The pathway has been highly conserved throughout evolution, and isoprenoids are some of the most ancient biomolecules ever identified, playing key roles in many life forms. In this review we focus on C-10 mono-, C-15 sesqui-, and C-20 diterpenes. Evidence for interconversion between the pathway intermediates farnesyl pyrophosphate and geranylgeranyl pyrophosphate and their respective metabolites is examined. The diverse functions of these molecules are discussed in detail, including their ability to regulate expression of the β-HMG-CoA reductase and Ras-related proteins. Additional topics include the mechanisms underlying the apoptotic effects of select isoprenoids, antiulcer activities, and the disposition and degradation of isoprenoids in the environment. Finally, the significance of pharmacological manipulation of the isoprenoid pathway and clinical correlations are discussed.

UR - http://www.scopus.com/inward/record.url?scp=3242785011&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=3242785011&partnerID=8YFLogxK

U2 - 10.1007/s11745-004-1233-3

DO - 10.1007/s11745-004-1233-3

M3 - Review article

C2 - 15357017

AN - SCOPUS:3242785011

VL - 39

SP - 293

EP - 309

JO - Lipids

JF - Lipids

SN - 0024-4201

IS - 4

ER -