Isosorbide Dinitrate

Effect on the Vasodilator Response to Nitroglycerin

Robert Zelis, Dean T. Mason

Research output: Contribution to journalArticle

85 Citations (Scopus)

Abstract

To evaluate whether there is cross-tolerance to the circulatory effects of isosorbide dinitrate and nitroglycerin, six subjects were given 120 mg/day of sustained-action isosorbide dinitrate in three divided doses for six to eight weeks. Prior to and during the last week of long-term isosorbide dinitrate administration, the effects of sublingually given nitroglycerin (0.9 mg) on plethysmographically measured calf blood flow and venous volume at 30 mm Hg (VV[30]) were measured on three occasions and averaged. Although the arteriolar dilation produced by nitroglycerin was unaltered by isosorbide dinitrate, the venodilation was significantly attenuated. The VV[30] increased from 3.00 to 3.28 ml/100 ml (P <.02) with nitroglycerin prior to isosorbide dinitrate administration, but failed to increase with nitroglycerin during the long-term administration of isosorbide dinitrate (2.95 to 2.95 ml/100 ml, P>.5).

Original languageEnglish (US)
Pages (from-to)166-170
Number of pages5
JournalJAMA: The Journal of the American Medical Association
Volume234
Issue number2
DOIs
StatePublished - Oct 13 1975

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Isosorbide Dinitrate
Nitroglycerin
Vasodilator Agents
Dilatation

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

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title = "Isosorbide Dinitrate: Effect on the Vasodilator Response to Nitroglycerin",
abstract = "To evaluate whether there is cross-tolerance to the circulatory effects of isosorbide dinitrate and nitroglycerin, six subjects were given 120 mg/day of sustained-action isosorbide dinitrate in three divided doses for six to eight weeks. Prior to and during the last week of long-term isosorbide dinitrate administration, the effects of sublingually given nitroglycerin (0.9 mg) on plethysmographically measured calf blood flow and venous volume at 30 mm Hg (VV[30]) were measured on three occasions and averaged. Although the arteriolar dilation produced by nitroglycerin was unaltered by isosorbide dinitrate, the venodilation was significantly attenuated. The VV[30] increased from 3.00 to 3.28 ml/100 ml (P <.02) with nitroglycerin prior to isosorbide dinitrate administration, but failed to increase with nitroglycerin during the long-term administration of isosorbide dinitrate (2.95 to 2.95 ml/100 ml, P>.5).",
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Isosorbide Dinitrate : Effect on the Vasodilator Response to Nitroglycerin. / Zelis, Robert; Mason, Dean T.

In: JAMA: The Journal of the American Medical Association, Vol. 234, No. 2, 13.10.1975, p. 166-170.

Research output: Contribution to journalArticle

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T1 - Isosorbide Dinitrate

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AU - Mason, Dean T.

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N2 - To evaluate whether there is cross-tolerance to the circulatory effects of isosorbide dinitrate and nitroglycerin, six subjects were given 120 mg/day of sustained-action isosorbide dinitrate in three divided doses for six to eight weeks. Prior to and during the last week of long-term isosorbide dinitrate administration, the effects of sublingually given nitroglycerin (0.9 mg) on plethysmographically measured calf blood flow and venous volume at 30 mm Hg (VV[30]) were measured on three occasions and averaged. Although the arteriolar dilation produced by nitroglycerin was unaltered by isosorbide dinitrate, the venodilation was significantly attenuated. The VV[30] increased from 3.00 to 3.28 ml/100 ml (P <.02) with nitroglycerin prior to isosorbide dinitrate administration, but failed to increase with nitroglycerin during the long-term administration of isosorbide dinitrate (2.95 to 2.95 ml/100 ml, P>.5).

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