Jaspamides H-L, new actin-targeting depsipeptides from the sponge Jaspis splendans

Fulvio Gala, Maria Valeria D'Auria, Simona De Marino, Valentina Sepe, Franco Zollo, Charles D. Smith, Jean E. Copper, Angela Zampella

Research output: Contribution to journalArticle

23 Scopus citations

Abstract

Continued investigation of cytotoxic extracts of the marine sponge Jaspis splendans has resulted in the discovery of jaspamides H-L (2-5). Their structures were determined by interpretation of their NMR and ESIMS data. All compounds exhibited potent cytotoxic activities and were shown to cause microfilament disruption. Biological activity and structural elucidation are reported here.

Original languageEnglish (US)
Pages (from-to)7127-7130
Number of pages4
JournalTetrahedron
Volume64
Issue number30-31
DOIs
StatePublished - Jul 21 2008

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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    Gala, F., D'Auria, M. V., De Marino, S., Sepe, V., Zollo, F., Smith, C. D., Copper, J. E., & Zampella, A. (2008). Jaspamides H-L, new actin-targeting depsipeptides from the sponge Jaspis splendans. Tetrahedron, 64(30-31), 7127-7130. https://doi.org/10.1016/j.tet.2008.05.037