Jaspamides M-P: new tryptophan modified jaspamide derivatives from the sponge Jaspis splendans

Fulvio Gala, Maria Valeria D'Auria, Simona De Marino, Valentina Sepe, Franco Zollo, Charles Smith, Staci N. Keller, Angela Zampella

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

Four new jaspamide derivatives with antimicrofilament activity were isolated from the marine sponge Jaspis splendans. Their structures were elucidated by NMR and MS analysis. A structure-activity relationship analysis on all natural jaspamides is also reported here.

Original languageEnglish (US)
Pages (from-to)51-56
Number of pages6
JournalTetrahedron
Volume65
Issue number1
DOIs
StatePublished - Jan 3 2009

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Organic Chemistry
  • Drug Discovery

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    Gala, F., D'Auria, M. V., De Marino, S., Sepe, V., Zollo, F., Smith, C., Keller, S. N., & Zampella, A. (2009). Jaspamides M-P: new tryptophan modified jaspamide derivatives from the sponge Jaspis splendans. Tetrahedron, 65(1), 51-56. https://doi.org/10.1016/j.tet.2008.10.076