JIL-1, a chromosomal kinase implicated in regulation of chromatin structure, associates with the male specific lethal (MSL) dosage compensation complex

Ye Jin, Yanming Wang, Jørgen Johansen, Kristen M. Johansen

Research output: Contribution to journalArticle

117 Citations (Scopus)

Abstract

JIL-1 is a novel chromosomal kinase that is upregulated almost twofold on the male X chromosome in Drosophila. Here we demonstrate that JIL-1 colocalizes and physically interacts with male specific lethal (MSL) dosage compensation complex proteins. Furthermore, ectopic expression of the MSL complex directed by MSL2 in females causes a concomitant upregulation of JIL- 1 to the female X that is abolished in msl mutants unable to assemble the complex. Thus, these results strongly indicate JIL-1 associates with the MSL complex and further suggests JIL-1 functions in signal transduction pathways regulating chromatin structure.

Original languageEnglish (US)
Pages (from-to)1005-1010
Number of pages6
JournalJournal of Cell Biology
Volume149
Issue number5
DOIs
StatePublished - May 29 2000

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Chromatin
Phosphotransferases
X Chromosome
Drosophila
Signal Transduction
Up-Regulation
Proteins

All Science Journal Classification (ASJC) codes

  • Cell Biology

Cite this

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abstract = "JIL-1 is a novel chromosomal kinase that is upregulated almost twofold on the male X chromosome in Drosophila. Here we demonstrate that JIL-1 colocalizes and physically interacts with male specific lethal (MSL) dosage compensation complex proteins. Furthermore, ectopic expression of the MSL complex directed by MSL2 in females causes a concomitant upregulation of JIL- 1 to the female X that is abolished in msl mutants unable to assemble the complex. Thus, these results strongly indicate JIL-1 associates with the MSL complex and further suggests JIL-1 functions in signal transduction pathways regulating chromatin structure.",
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JIL-1, a chromosomal kinase implicated in regulation of chromatin structure, associates with the male specific lethal (MSL) dosage compensation complex. / Jin, Ye; Wang, Yanming; Johansen, Jørgen; Johansen, Kristen M.

In: Journal of Cell Biology, Vol. 149, No. 5, 29.05.2000, p. 1005-1010.

Research output: Contribution to journalArticle

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