JIL-1, a chromosomal kinase implicated in regulation of chromatin structure, associates with the male specific lethal (MSL) dosage compensation complex

Ye Jin, Yanming Wang, Jørgen Johansen, Kristen M. Johansen

Research output: Contribution to journalArticle

117 Scopus citations

Abstract

JIL-1 is a novel chromosomal kinase that is upregulated almost twofold on the male X chromosome in Drosophila. Here we demonstrate that JIL-1 colocalizes and physically interacts with male specific lethal (MSL) dosage compensation complex proteins. Furthermore, ectopic expression of the MSL complex directed by MSL2 in females causes a concomitant upregulation of JIL- 1 to the female X that is abolished in msl mutants unable to assemble the complex. Thus, these results strongly indicate JIL-1 associates with the MSL complex and further suggests JIL-1 functions in signal transduction pathways regulating chromatin structure.

Original languageEnglish (US)
Pages (from-to)1005-1010
Number of pages6
JournalJournal of Cell Biology
Volume149
Issue number5
DOIs
StatePublished - May 29 2000

All Science Journal Classification (ASJC) codes

  • Cell Biology

Fingerprint Dive into the research topics of 'JIL-1, a chromosomal kinase implicated in regulation of chromatin structure, associates with the male specific lethal (MSL) dosage compensation complex'. Together they form a unique fingerprint.

  • Cite this