Kalman filter tracking of intracellular neuronal voltage and current

Yina Wei, Ghanim Ullah, Ruchi Parekh, Jokubas Ziburkus, Steven Schiff

Research output: Chapter in Book/Report/Conference proceedingConference contribution

7 Citations (Scopus)

Abstract

The nervous system encodes and processes information with the activities of neurons. The response of a single neuron is complex and depends on the interactions between its previous state, its intrinsic properties, and the stimuli it receives. Experimentally, we utilize the patch clamp technique to monitor neural membrane voltages, but the underlying stimuli, including the external current or synaptic current from other neurons, cannot be fully observed. In this paper, we used computational models as an alternative to tackle these challenges. We employed an ensemble Kalman filter to reconstruct unobserved intracellular variables and parameters only from measured membrane potentials in a CA1 pyramidal neuron model that follows Hodgkin-Huxley dynamics. We found that the tracking of intracellular neuronal voltage and current was close to their true values whether the observations are from model generated data or real experimental data. In addition, we retrieved the experimentally inaccessible dynamics of the neuron, such as the changes of sodium and potassium gating variables, which helps to understand their roles in generating action potentials. Our study provides a powerful framework for observing dynamics underlying neural activity and seeking better real-time neuronal control.

Original languageEnglish (US)
Title of host publication2011 50th IEEE Conference on Decision and Control and European Control Conference, CDC-ECC 2011
Pages5844-5849
Number of pages6
DOIs
StatePublished - Dec 1 2011
Event2011 50th IEEE Conference on Decision and Control and European Control Conference, CDC-ECC 2011 - Orlando, FL, United States
Duration: Dec 12 2011Dec 15 2011

Publication series

NameProceedings of the IEEE Conference on Decision and Control
ISSN (Print)0191-2216

Other

Other2011 50th IEEE Conference on Decision and Control and European Control Conference, CDC-ECC 2011
CountryUnited States
CityOrlando, FL
Period12/12/1112/15/11

Fingerprint

Kalman filters
Kalman Filter
Neurons
Neuron
Voltage
Electric potential
Patch Clamp
Ensemble Kalman Filter
Membrane Potential
Neuron Model
Action Potential
Membranes
Potassium
Sodium
Computational Model
Clamping devices
Neurology
Monitor
Membrane
Experimental Data

All Science Journal Classification (ASJC) codes

  • Control and Systems Engineering
  • Modeling and Simulation
  • Control and Optimization

Cite this

Wei, Y., Ullah, G., Parekh, R., Ziburkus, J., & Schiff, S. (2011). Kalman filter tracking of intracellular neuronal voltage and current. In 2011 50th IEEE Conference on Decision and Control and European Control Conference, CDC-ECC 2011 (pp. 5844-5849). [6161358] (Proceedings of the IEEE Conference on Decision and Control). https://doi.org/10.1109/CDC.2011.6161358
Wei, Yina ; Ullah, Ghanim ; Parekh, Ruchi ; Ziburkus, Jokubas ; Schiff, Steven. / Kalman filter tracking of intracellular neuronal voltage and current. 2011 50th IEEE Conference on Decision and Control and European Control Conference, CDC-ECC 2011. 2011. pp. 5844-5849 (Proceedings of the IEEE Conference on Decision and Control).
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Wei, Y, Ullah, G, Parekh, R, Ziburkus, J & Schiff, S 2011, Kalman filter tracking of intracellular neuronal voltage and current. in 2011 50th IEEE Conference on Decision and Control and European Control Conference, CDC-ECC 2011., 6161358, Proceedings of the IEEE Conference on Decision and Control, pp. 5844-5849, 2011 50th IEEE Conference on Decision and Control and European Control Conference, CDC-ECC 2011, Orlando, FL, United States, 12/12/11. https://doi.org/10.1109/CDC.2011.6161358

Kalman filter tracking of intracellular neuronal voltage and current. / Wei, Yina; Ullah, Ghanim; Parekh, Ruchi; Ziburkus, Jokubas; Schiff, Steven.

2011 50th IEEE Conference on Decision and Control and European Control Conference, CDC-ECC 2011. 2011. p. 5844-5849 6161358 (Proceedings of the IEEE Conference on Decision and Control).

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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Wei Y, Ullah G, Parekh R, Ziburkus J, Schiff S. Kalman filter tracking of intracellular neuronal voltage and current. In 2011 50th IEEE Conference on Decision and Control and European Control Conference, CDC-ECC 2011. 2011. p. 5844-5849. 6161358. (Proceedings of the IEEE Conference on Decision and Control). https://doi.org/10.1109/CDC.2011.6161358