Kaposi's sarcoma in two primary liver allograft recipients occurring under FK506 immunosuppression

Z. Kadry, O. Bronsther, D. H. Van Thiel, P. Randhawa, J. J. Fung, T. E. Starzl

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Abstract

Of 1463 liver allograft recipients receiving the combination of FK506 and steroids as their primary immunosuppressive regimen, 2 patients developed Kaposi's sarcoma. Although previously described as a complication of organ transplantation, this is the first case report of Kaposi's sarcoma occurring in association with the macrolide immunosuppressive agent FK506. A discussion of the clinical presentation and course of Kaposi's sarcoma in these 2 patients, as well as a review of the past literature on Kaposi's sarcoma in organ transplant recipients, emphasizes the therapeutic difficulties encountered. Kaposi's sarcoma is also compared to lymphoproliferative disorders, another well-recognized complication of immunosuppression, highlighting the differences between these two entities.

Original languageEnglish (US)
Pages (from-to)188-194
Number of pages7
JournalClinical Transplantation
Volume7
Issue number2
StatePublished - May 28 1993

All Science Journal Classification (ASJC) codes

  • Transplantation

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    Kadry, Z., Bronsther, O., Van Thiel, D. H., Randhawa, P., Fung, J. J., & Starzl, T. E. (1993). Kaposi's sarcoma in two primary liver allograft recipients occurring under FK506 immunosuppression. Clinical Transplantation, 7(2), 188-194.