Kappa opioid receptor signaling in the brain: Circuitry and implications for treatment

Nicole A. Crowley, Thomas L. Kash

Research output: Contribution to journalArticlepeer-review

52 Scopus citations

Abstract

Kappa opioid receptors (KORs) in the central nervous system have been known to be important regulators of a variety of psychiatry illnesses, including anxiety and addiction, but their precise involvement in these disorders is complex and has yet to be fully elucidated. Here, we briefly review the pharmacology of KORs in the brain, including KOR's involvement in anxiety, depression, and drug addiction. We also review the known neuronal circuitry impacted by KOR signaling, and interactions with corticotrophin-releasing factor (CRF), another key peptide in anxiety-related illnesses, as well as the role of glucocorticoids. We suggest that KORs are a promising therapeutic target for a host of neuropsychiatric conditions.

Original languageEnglish (US)
Pages (from-to)51-60
Number of pages10
JournalProgress in Neuro-Psychopharmacology and Biological Psychiatry
Volume62
DOIs
StatePublished - Oct 1 2015

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Biological Psychiatry

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