Abstract
Interphase eukaryotic nuclei contain diffuse euchromatin and condensed heterochromatin. Current textbook models suggest that chromatin condensation occurs via accordion-type compaction of nucleosome zigzag chains. Recent studies have revealed several structural aspects that distinguish the highly compact state of condensed heterochromatin. These include an extensive lateral self-association of chromatin fibers, prominent nucleosome linker 'stems', and special protein factors that promote chromatin self-association. Here I review the molecular and structural determinants of chromatin compaction and discuss how heterochromatin spreading may be mediated by lateral self-association of zigzag nucleosome arrays.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 4-8 |
| Number of pages | 5 |
| Journal | FEBS Letters |
| Volume | 564 |
| Issue number | 1-2 |
| DOIs | |
| State | Published - Apr 23 2004 |
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All Science Journal Classification (ASJC) codes
- Biophysics
- Structural Biology
- Biochemistry
- Molecular Biology
- Genetics
- Cell Biology
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Keeping fingers crossed : Heterochromatin spreading through interdigitation of nucleosome arrays. / Grigoryev, Sergei.
In: FEBS Letters, Vol. 564, No. 1-2, 23.04.2004, p. 4-8.Research output: Contribution to journal › Short survey
TY - JOUR
T1 - Keeping fingers crossed
T2 - Heterochromatin spreading through interdigitation of nucleosome arrays
AU - Grigoryev, Sergei
PY - 2004/4/23
Y1 - 2004/4/23
N2 - Interphase eukaryotic nuclei contain diffuse euchromatin and condensed heterochromatin. Current textbook models suggest that chromatin condensation occurs via accordion-type compaction of nucleosome zigzag chains. Recent studies have revealed several structural aspects that distinguish the highly compact state of condensed heterochromatin. These include an extensive lateral self-association of chromatin fibers, prominent nucleosome linker 'stems', and special protein factors that promote chromatin self-association. Here I review the molecular and structural determinants of chromatin compaction and discuss how heterochromatin spreading may be mediated by lateral self-association of zigzag nucleosome arrays.
AB - Interphase eukaryotic nuclei contain diffuse euchromatin and condensed heterochromatin. Current textbook models suggest that chromatin condensation occurs via accordion-type compaction of nucleosome zigzag chains. Recent studies have revealed several structural aspects that distinguish the highly compact state of condensed heterochromatin. These include an extensive lateral self-association of chromatin fibers, prominent nucleosome linker 'stems', and special protein factors that promote chromatin self-association. Here I review the molecular and structural determinants of chromatin compaction and discuss how heterochromatin spreading may be mediated by lateral self-association of zigzag nucleosome arrays.
UR - http://www.scopus.com/inward/record.url?scp=1842861622&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=1842861622&partnerID=8YFLogxK
U2 - 10.1016/S0014-5793(04)00258-3
DO - 10.1016/S0014-5793(04)00258-3
M3 - Short survey
C2 - 15094034
AN - SCOPUS:1842861622
VL - 564
SP - 4
EP - 8
JO - FEBS Letters
JF - FEBS Letters
SN - 0014-5793
IS - 1-2
ER -