@article{0ce5779c34fe4ae2adb7a3020bfc7c34,
title = "Keeping weight off: Mindfulness-Based Stress Reduction alters amygdala functional connectivity during weight loss maintenance in a randomized control trial",
abstract = "Obesity is associated with significant comorbidities and financial costs. While behavioral interventions produce clinically meaningful weight loss, weight loss maintenance is challenging. The objective was to improve understanding of the neural and psychological mechanisms modified by mindfulness that may predict clinical outcomes. Individuals who intentionally recently lost weight were randomized to Mindfulness-Based Stress Reduction (MBSR) or a control healthy living course. Anthropometric and psychological factors were measured at baseline, 8 weeks and 6 months. Functional connectivity (FC) analysis was performed at baseline and 8 weeks to examine FC changes between regions of interest selected a priori, and independent components identified by independent component analysis. The association of pre-post FC changes with 6-month weight and psychometric outcomes was then analyzed. Significant group x time interaction was found for FC between the amygdala and ventromedial prefrontal cortex, such that FC increased in the MBSR group and decreased in controls. Non-significant changes in weight were observed at 6 months, where the mindfulness group maintained their weight while the controls showed a weight increase of 3.4% in BMI. Change in FC at 8-weeks between ventromedial prefrontal cortex and several ROIs was associated with change in depression symptoms but not weight at 6 months. This pilot study provides preliminary evidence of neural mechanisms that may be involved in MBSR{\textquoteright}s impact on weight loss maintenance that may be useful for designing future clinical trials and mechanistic studies.",
author = "Chumachenko, {Serhiy Y.} and Cali, {Ryan J.} and Rosal, {Milagros C.} and Allison, {Jeroan J.} and Person, {Sharina J.} and Douglas Ziedonis and Nephew, {Benjamin C.} and Moore, {Constance M.} and Nanyin Zhang and King, {Jean A.} and Carl Fulwiler",
note = "Funding Information: The National Center for Complementary and Integrative Health (NCCIH)) provided funding for this trial (grants R34AT006963 and R34 AT006963-01A1 to manuscript authors/principal investigators CF and JAK). The design of this trial was reviewed and approved by NCCIH{\textquoteright}s Office of Clinical and Regulatory Affairs. Support was also provided by an award from the UMMS Department of Radiology. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health or the UMMS Department of Radiology Advanced MR Imaging Center. Neither the funding organizations nor any other entities played any role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. No other entities such as commercial companies played a role in funding this study or paid salaries or gave benefits to any of the authors. No sponsors or funders (other than the named authors) played any role in, study design, data collection and analysis, decision to publish, or preparation of the manuscript. The authors thank Drs. Shaokuan Zheng, Wei Huang, Guillaume Poirier, and Poornima Kumar for technical assistance; Dr. Asimina Lazaridou, Marcela Hayes, Emily Levoy, Julia Siegel, Garen Koutoujian, Mark Fusunyan, Dr. Gertrude Manchester, and Dr. Nivedita Gour for their helpful contributions to the study. We thank Drs. Lori Pbert and Sarah Reiff-Hekking, developers of the Health Living Course, for sharing their expertise with the intervention. We thank the Conquering Disease Program for help with recruiting. We also extend our sincere gratitude to the staff and teachers of the Center for Mindfulness for their assistance. The project was conducted at the UMMS Advanced MR Imaging Center. Publisher Copyright: {\textcopyright} 2021 Chumachenko et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.",
year = "2021",
month = jan,
doi = "10.1371/journal.pone.0244847",
language = "English (US)",
volume = "16",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "1 January",
}