Keratins Are Going Nuclear

Ryan Hobbs, Justin T. Jacob, Pierre A. Coulombe

Research output: Contribution to journalComment/debate

16 Citations (Scopus)

Abstract

Previously thought to reside exclusively in the cytoplasm, the cytoskeletal protein keratin 17 (K17) has been recently identified inside the nucleus of tumor epithelial cells with a direct impact on cell proliferation and gene expression. We comment on fundamental questions raised by this new finding and the associated significance.

Original languageEnglish (US)
Pages (from-to)227-233
Number of pages7
JournalDevelopmental Cell
Volume38
Issue number3
DOIs
StatePublished - Aug 8 2016

Fingerprint

Keratin-17
Cytoskeletal Proteins
Cell proliferation
Keratins
Gene expression
Tumors
Cytoplasm
Epithelial Cells
Cell Proliferation
Gene Expression
Neoplasms

All Science Journal Classification (ASJC) codes

  • Developmental Biology

Cite this

Hobbs, Ryan ; Jacob, Justin T. ; Coulombe, Pierre A. / Keratins Are Going Nuclear. In: Developmental Cell. 2016 ; Vol. 38, No. 3. pp. 227-233.
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Hobbs, R, Jacob, JT & Coulombe, PA 2016, 'Keratins Are Going Nuclear' Developmental Cell, vol. 38, no. 3, pp. 227-233. https://doi.org/10.1016/j.devcel.2016.07.022

Keratins Are Going Nuclear. / Hobbs, Ryan; Jacob, Justin T.; Coulombe, Pierre A.

In: Developmental Cell, Vol. 38, No. 3, 08.08.2016, p. 227-233.

Research output: Contribution to journalComment/debate

TY - JOUR

T1 - Keratins Are Going Nuclear

AU - Hobbs, Ryan

AU - Jacob, Justin T.

AU - Coulombe, Pierre A.

PY - 2016/8/8

Y1 - 2016/8/8

N2 - Previously thought to reside exclusively in the cytoplasm, the cytoskeletal protein keratin 17 (K17) has been recently identified inside the nucleus of tumor epithelial cells with a direct impact on cell proliferation and gene expression. We comment on fundamental questions raised by this new finding and the associated significance.

AB - Previously thought to reside exclusively in the cytoplasm, the cytoskeletal protein keratin 17 (K17) has been recently identified inside the nucleus of tumor epithelial cells with a direct impact on cell proliferation and gene expression. We comment on fundamental questions raised by this new finding and the associated significance.

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DO - 10.1016/j.devcel.2016.07.022

M3 - Comment/debate

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SP - 227

EP - 233

JO - Developmental Cell

JF - Developmental Cell

SN - 1534-5807

IS - 3

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